Michael I Bernhard

US Patent:

6496727, Dec 17, 2002

Filed:

May 31, 2000

Appl. No.:

09/584453

Inventors:

Michael I. Bernhard - Summit NJ
Ralph Ewall - Long Valley NJ
Curtis Karl - Somerset NJ
Preston Keusch - Hazlet NJ
Gary Kupperblatt - Belle Mead NJ
Daniel OGrady - Edison NJ

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61N 130

US Classification:

604 20

Abstract:

A transdermal reservoir and method for loading a material into a reservoir includes providing a bibulous reservoir blocking a backing with an interior surface having a patient contact surface with a shape disposed on the interior surface of the backing. A closure is sized and shaped to engage the backing for forming a releasable seal to isolate the bibulous reservoir from the ambient environment. The closure has an inside surface with a section of an absorbent material disposed thereon. When the closure is disposed on the backing, the absorbent material is positioned in intimate physical contact with the reservoir. The method includes applying an aliquot of a material to the absorbent material,. placing the closure on the backing so that the absorbent material is in intimate physical contact with the contact surface of the bibulous reservoir and the closure forms the releasable seal with the backing. The reservoir is allowed to stand for a sufficient time to allow the aliquot to be absorbed into the bibulous material thereby loading the reservoir.

US Patent:

20030065304, Apr 3, 2003

Filed:

Oct 18, 2002

Appl. No.:

10/274533

Inventors:

Michael Bernhard - Summit NJ, US
Ralph Ewall - Long Valley NJ, US
Curtis Karl - Somerset NJ, US
Preston Keusch - Hazlet NJ, US
Gary Kupperblatt - Belle Mead NJ, US
Daniel O'Grady - Edison NJ, US

Assignee:

Becton, Dickinson and Company

International Classification:

A61N001/30

US Classification:

604/500000, 604/020000

Abstract:

A transdermal reservoir and a method of the present invention for loading a material into a reservoir includes providing an reservoir including a backing with an interior surface comprising a bibulous reservoir having a patient contact surface with a shape disposed on the interior surface of the backing. The method includes providing a closure sized and shaped to engage the backing for forming a releasable seal to isolate the bibulous reservoir from the ambient environment, the closure is removable from the housing to expose the patient contact surface for use. The provided closure has an inside surface with a section of an absorbent material disposed thereon. The provided section has a first surface so that when the closure is disposed on the backing, the absorbent material first surface is positioned in intimate physical contact with the reservoir. The method includes applying an aliquot of a material to the absorbent material. The method further includes placing the closure on the backing so that the first surface of said absorbent material is in intimate physical contact with the contact surface of the bibulous reservoir and the closure forms the releasable seal with the backing. The method includes allowing the reservoir—with the closure applied thereto to stand for a sufficient time to allow the aliquot of the material to be absorbed into the bibulous material thereby loading the reservoir.

US Patent:

57386471, Apr 14, 1998

Filed:

Sep 27, 1996

Appl. No.:

8/722813

Inventors:

Michael I. Bernhard - Summit NJ
John D. DeNuzzio - Chapel Hill NC

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

A61N 130

US Classification:

604 20

Abstract:

A user activated iontophoretic device of the present invention includes an electrode assembly, an electrode reservoir and at least one drug reservoir. The device is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. The electrode reservoir and the drug reservoir are sealingly separated by a barrier, which can be removed to bring the reservoirs into fluid conducting contact with one another. A method of activating the device includes causing the two portions to come into fluid conducting contact with one another to at least partially hydrate one of the reservoirs. This can be accomplished by removing the barrier dividing the two portions. In this way, the device is suitable for use to deliver a drug which has limited stability in an aqueous solution.

US Patent:

59191562, Jul 6, 1999

Filed:

Sep 27, 1996

Appl. No.:

8/722760

Inventors:

Scott Edward Stropkay - Carlisle MA
Michael I. Bernhard - Summit NJ

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61N 130

US Classification:

604 20

Abstract:

An iontophoretic drug delivery system including a plurality of patches, at least one reusable controller and a unit for storing and dispensing the patches. The patches may be secured in a compartment formed in the unit and the controller may be stored in another compartment formed in the unit. In this way, the reusable controller and a new patch can be removed from the unit and fastened to one another for activation and attachment to the skin of a patient.

US Patent:

57138460, Feb 3, 1998

Filed:

Sep 27, 1996

Appl. No.:

8/722814

Inventors:

Michael I. Bernhard - Summit NJ
John D. DeNuzzio - Chapel Hill NC

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

A61N 130

US Classification:

604 20

Abstract:

An iontophoretic drug delivery system including a patch, a controller and a magazine. The patch may be secured in a compartment formed in the magazine so that upon insertion of the controller along the magazine to fasten the controller to the patch, a dry drug contained in the patch is hydrated and the patch and controller can be removed from the magazine for attachment to the skin of a patient.

US Patent:

57978670, Aug 25, 1998

Filed:

Sep 27, 1996

Appl. No.:

8/722816

Inventors:

Stephen K. Guerrera - Milford MA
Michael I. Bernhard - Summit NJ

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

A61N 130

US Classification:

604 20

Abstract:

The user activated iontophoretic device of the present invention includes a disposable patch and a reusable controller. The patch contains an electrode assembly, an electrode reservoir and at least one drug reservoir. The patch is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. The electrode reservoir and the drug reservoir are sealingly separated by a barrier, which can be manipulated to bring the reservoirs into fluid conducting contact with one another. A method of activating the device includes causing the two portions to rotate about a central axis relative to one another to manipulate the barrier and bring the reservoirs into fluid conducting contact with one another to at least partially hydrate one of the reservoirs. In this way, the device is suitable for use to deliver a drug which has limited stability in an aqueous solution.