Michael S Braverman

US Patent:

20050221341, Oct 6, 2005

Filed:

Oct 22, 2004

Appl. No.:

10/971614

Inventors:

Richard Shimkets - Guilford CT, US
Michael Braverman - New Haven CT, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435006000, 702020000

Abstract:

A new method for genomic analysis, termed “Sequence-Based Karyotyping,” is described. Sequence-Based Karyotyping methods for the detection of genomic abnormalities, for diagnosis of hereditary disease, or for diagnosis of spontaneous genomic mutations are also described.

US Patent:

20090105959, Apr 23, 2009

Filed:

May 29, 2008

Appl. No.:

12/156242

Inventors:

Michael S. Braverman - New Haven CT, US
Jan Fredrik Simons - San Francisco CA, US
Maithreyan Srinivasan - Mountain View CA, US
Gregory S. Turenchalk - New Haven CT, US

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

An embodiment of an identifier element for identifying an origin of a template nucleic acid molecule is described that comprises a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, where the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule.

US Patent:

20100267043, Oct 21, 2010

Filed:

May 5, 2010

Appl. No.:

12/800043

Inventors:

Michael S. Braverman - New Haven CT, US
Jan Fredrik Simons - San Francisco CA, US
Maithreyan Srinivasan - Mountain View CA, US
Gregory S. Turenchalk - New Haven CT, US

International Classification:

C12Q 1/68
G06F 19/00

US Classification:

435 6, 702 19

Abstract:

An embodiment of an identifier element for identifying an origin of a template nucleic acid molecule is described that comprises a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, where the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule.

US Patent:

20110003701, Jan 6, 2011

Filed:

Feb 23, 2009

Appl. No.:

12/380139

Inventors:

Gianni Calogero Ferreri - Northford CT, US
Jan F. Simons - San Francisco CA, US
Michael Todd Ronan - New York NY, US
Michael Egholm - Madison CT, US
Brian C. Godwin - North Haven CT, US
David Roderick Riches - Hamden CT, US
Stephen Kyle Hutchison - Branford CT, US
Michael S. Braverman - New Haven CT, US
Melinda D. Palmer - Hamden CT, US
Jeffrey Jeddeloh - Verona WI, US
Jacob Kitzman - Seattle WA, US
Thomas J. Albert - Verona WI, US

International Classification:

C40B 30/04
C07H 21/00
C12P 19/34
C12Q 1/68
C07H 21/04

US Classification:

506 9, 536 231, 435 912, 435 6

Abstract:

An embodiment of an adaptor element for efficient target processing is described that comprises a semi-complementary double stranded nucleic acid adaptor comprising a non-complementary region and a complementary region, where the non-complementary region comprises a first amplification primer site and a second amplification primer site and the complementary region comprises a sequencing primer site and one or more inosine species.