Michael D Chapman

US Patent:

20180327752, Nov 15, 2018

Filed:

Nov 9, 2016

Appl. No.:

15/774223

Inventors:

- Stanford CA, US
- Portland OR, US
Michael Stewart Chapman - Lake Oswego OR, US
Nancy Meyer - Portland OR, US
Andreas Puschnik - Palo Alto CA, US
Omar Davulcu - Portland OR, US

International Classification:

C12N 15/113
C12N 15/85

Abstract:

Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.