Michael Chorny

US Patent:

7846201, Dec 7, 2010

Filed:

Oct 14, 2005

Appl. No.:

11/250948

Inventors:

Michael Chorny - Philadelphia PA, US
Boris Polyak - Philadelphia PA, US
Ilia Fishbein - Philadelphia PA, US
Ivan Alferiev - Clementon NJ, US
Robert J. Levy - Merion Station PA, US

Assignee:

The Children's Hospital of Philadelphia - Philadelphia PA

International Classification:

A61F 2/02

US Classification:

623 142, 424646, 600 12, 604507

Abstract:

A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.

US Patent:

8263127, Sep 11, 2012

Filed:

Dec 8, 2009

Appl. No.:

12/633593

Inventors:

Ivan Alferiev - Clementon NJ, US
Ilia Fishbein - Philadelphia PA, US
Michael Chorny - Philadelphia PA, US
Robert J. Levy - Merion Station PA, US
Benjamin Yellen - Durham PA, US
Darryl Williams - Philadelphia PA, US

Assignee:

The Children's Hospital of Philadelphia - Philadelphia PA

International Classification:

A61K 9/14
A61K 47/48

US Classification:

424484, 525 541

Abstract:

A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

US Patent:

8562505, Oct 22, 2013

Filed:

May 1, 2008

Appl. No.:

12/150864

Inventors:

Robert J. Levy - Merion Station PA, US
Boris Polyak - Philadelphia PA, US
Michael Chorny - Philadelphia PA, US
Ivan Alferiev - Clementon NJ, US
Gennady Friedman - Richboro PA, US
Darryl Williams - Philadelphia PA, US
Ilia Fishbein - Philadelphia PA, US

Assignee:

The Children's Hospital of Philadelphia - Philadelphia PA
Drexel University - Philadelphia PA

International Classification:

A61N 2/10

US Classification:

600 12, 600 9, 600 13, 600 15, 424422, 424426

Abstract:

Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

US Patent:

20060147413, Jul 6, 2006

Filed:

Oct 14, 2005

Appl. No.:

11/250877

Inventors:

Ivan Alferiev - Clementon NJ, US
Ilia Fishbein - Philadelphia PA, US
Michael Chorny - Philadelphia PA, US
Robert Levy - Merion Station PA, US
Benjamin Yellen - Durham PA, US
Darryl Williams - Philadelphia PA, US

International Classification:

A61K 31/785
A61K 31/765
C08F 271/02

US Classification:

424078270, 424078300, 525279000

Abstract:

A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

US Patent:

20070116768, May 24, 2007

Filed:

Dec 9, 2004

Appl. No.:

10/582266

Inventors:

Michael Chorny - Philadelphia PA, US
Robert Levy - Merion Station PA, US

International Classification:

A61K 39/395
A61K 38/22
A61K 38/18
A61K 31/715
A61K 9/14

US Classification:

424489000, 514012000, 514054000, 424133100

Abstract:

A particle includes a complex between a bioactive agent and a complexing agent, provided that the bioactive agent is other than a polynucleotide and an oligonucleotide, and wherein the particle has a bioactive function. The particle has a diameter from about 5 nm to about 100 microns. In certain embodiments, the bioactive agent is a member selected from the group consisting of a growth factor, a hormone, a peptide, a protein, and polysaccharide. In certain embodiments, the complexing agent is a member selected from the group consisting of polysaccharides, glycosaminoglycans, complex carbohydrates, polyacids, modifications and derivatives thereof. Also provided is a method of making the particle. Further provided is a method of administering the particle, including providing the particle, which is adapted to gradually release the bioactive agent; and thereby administering the particle.

US Patent:

20090216320, Aug 27, 2009

Filed:

Apr 20, 2007

Appl. No.:

12/297971

Inventors:

Robert J. Levy - Merion Station PA, US
Michael Chorny - Philadelphia PA, US
Ilia Fishbein - Philadelphia PA, US
Gennady Friedman - Richboro PA, US
Boris Polyak - Philadelphia PA, US
Darryl Williams - Philadelphia PA, US

Assignee:

The Children's Hospital of Philadelphia - Philadelphia PA
Drexel University - Philadelphia PA

International Classification:

A61M 37/00
A61N 2/00
A61F 2/82

US Classification:

623 142, 600 12, 604500

Abstract:

A therapeutic system and a method that uses stents, and/or other implantable devices () for local delivery of a therapeutic agent is disclosed. A therapeutic formulation () may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells. The therapeutic formulation () is intravenously administered to a mammalian subject. A portion of the formulation () is delivered to the proximity of a device () implanted in the vascular system of the subject by externally generating a magnetic field gradient () on the implantable device (). The portion of the therapeutic formulation () not delivered to the proximity of the implantable device () is removed from the vascular system. The method allows for the repeated administration of the same or different therapeutic agent, and further, has the option of locally injecting, or alternatively, peripherally administering, the therapeutic agent.

US Patent:

20100260780, Oct 14, 2010

Filed:

Dec 15, 2009

Appl. No.:

12/653465

Inventors:

Robert J. Levy - Merion Station PA, US
Michael Chorny - Huntingdon Valley PA, US
Vladimir Muzykantov - Warwick PA, US
Elizabeth Hood - Philadelphia PA, US

Assignee:

The Children's Hospital of Philadelphia - Philadelphia PA
The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 39/44
A61N 2/10
A61F 2/82
A61M 31/00
A61K 38/44
A61P 43/00
C12N 13/00

US Classification:

4241721, 600 12, 623 142, 604500, 424 944, 4241301, 4241781, 4351735

Abstract:

Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.

US Patent:

20120184941, Jul 19, 2012

Filed:

Jul 21, 2010

Appl. No.:

13/384509

Inventors:

Robert J. Levy - Merion Station PA, US
Michael Chorny - Philadelphia PA, US
Jeanne M. Connolly - Philadelphia PA, US

Assignee:

The Children's Hosital of Philadelphia - Philadelphia PA

International Classification:

A61M 25/00
A61M 37/00

US Classification:

604522, 604264, 604500

Abstract:

The invention features devices, systems, and methods for targeted delivery of therapeutic agents in magnetic particle carriers to desired locations on tissue in the body. The systems and methods utilize at least one device comprising a source of magnetization, and at least one device comprising a magnetic or magnetizable material, to facilitate close tissue apposition and sealing, and to facilitate site-specific delivery of magnetic particles comprising therapeutic agents.