Michael D Conn

US Patent:

20050142545, Jun 30, 2005

Filed:

Apr 11, 2002

Appl. No.:

10/475026

Inventors:

Michael Conn - New York NY, US
Matthew Pelligrini - Bedminster NJ, US
Seongwoo Hwang - Edison NJ, US
Young-Choon Moon - Belle Mead NJ, US
Neil Almstead - Holmdel NJ, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (“RNA”). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

US Patent:

20060194234, Aug 31, 2006

Filed:

Feb 21, 2006

Appl. No.:

11/359721

Inventors:

Michael Conn - New York NY, US
Mathew Pelligrini - Bedminster NJ, US
Seongwoo Hwang - Edison NJ, US
Young-Choon Moon - Belle Mead NJ, US
Neil Almstead - Holmdel NJ, US

International Classification:

C40B 40/08

US Classification:

435006000

Abstract:

The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (“RNA”). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.