Michael S Cosgrove

US Patent:

20100022002, Jan 28, 2010

Filed:

Jul 27, 2009

Appl. No.:

12/509874

Inventors:

Michael S. Cosgrove - Syracuse NY, US
Anamika Patel - Syracuse NY, US

International Classification:

C12N 5/07

US Classification:

435375

Abstract:

Disclosed in this specification is a method for inhibiting the formation of SET1 family core complexes. A guanidinium-containing molecule is used to competitively inhibit the binding of the N-SET region of a SET1 protein to WDR5, thus inhibiting the formation of the SET1 family core complex. The guanidinium-containing molecule may be, for example, an arginine-containing peptide. When bound to WDR5, the guanidinium moiety is bound between the F-133 and F-263 residues of the WDR5 when a crystal structure of the bound complex is obtained.

US Patent:

20130203167, Aug 8, 2013

Filed:

Mar 8, 2012

Appl. No.:

13/415474

Inventors:

Michael S. Cosgrove - Syracuse NY, US
Anamika Patel - Syracuse NY, US

Assignee:

Syracuse University - Syracuse NY

International Classification:

C12N 9/99

US Classification:

435375

Abstract:

Disclosed in this specification is a method for inhibiting the formation of vertebrate SET1 family core complexes. A guanidinium-containing molecule is used to competitively inhibit the binding of the N-SET region of a SET1 protein to WDR5, thus inhibiting the formation of the SET1 family core complex. The guanidinium-containing molecule may be, for example, an arginine-containing peptide.