Michael Roy Danielson

US Patent:

7943609, May 17, 2011

Filed:

Dec 29, 2005

Appl. No.:

11/813039

Inventors:

George W. Griesgraber - Eagan MN, US
Tushar A. Kshirsagar - Woodbury MN, US
Azim A. Celebi - Kenilworth NJ, US
Sarah J. Slania - Minneapolis MN, US
Michael E. Danielson - Saint Paul MN, US
Michael J. Rice - Oakdale MN, US
Joshua R. Wurst - Saint Paul MN, US

Assignee:

3M Innovative Proprerties Company - St. Paul MN

International Classification:

A61K 31/4745
C07D 487/22

US Classification:

5142295, 5142302, 544 99, 544101

Abstract:

Fused [1,2]imidazo[4,5-c] ring compounds (e. g. , imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X—R)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

US Patent:

8138173, Mar 20, 2012

Filed:

Mar 31, 2006

Appl. No.:

11/887526

Inventors:

Bryon A. Merrill - River Falls WI, US
Michael E. Danielson - Saint Paul MN, US
David S. Hays - Woodbury MN, US
David T. Amos - Saint Paul MN, US
Philip D. Heppner - Forest Lake MN, US
Tushar A. Kshirsagar - Woodbury MN, US
William H. Moser - St. Paul MN, US

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

A61K 31/55
A61K 31/437
C07D 471/04

US Classification:

51421707, 514303, 514293, 546119, 546 82, 540597

Abstract:

Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg. , 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.

US Patent:

8158794, Apr 17, 2012

Filed:

Feb 22, 2006

Appl. No.:

11/885006

Inventors:

Tushar A. Kshirsagar - Woodbury MN, US
Bryon A. Merrill - River Falls WI, US
Shri Niwas - Maple Grove MN, US
Philip D. Heppner - Forest Lake MN, US
Michael E. Danielson - Saint Paul MN, US

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C07D 471/00
A61K 31/535

US Classification:

546 82, 5142228

Abstract:

Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

US Patent:

20090030031, Jan 29, 2009

Filed:

Feb 22, 2006

Appl. No.:

11/884982

Inventors:

Tushar A. Kshirsagar - Woodbury MN, US
Bryon A. Merrill - River Falls WI, US
Scott E. Langer - Woodbury MN, US
Kyle J. Lindstrom - Houlton WI, US
Sarah C. Slania - Minneapolis MN, US
Gregory J. Marszalek - Woodbury MN, US
Joshua R. Wurst - Saint Paul MN, US
Karl J. Manske - Minneapolis MN, US
Shri Niwas - Maple Grove MN, US
Philip D. Heppner - Forest Lake MN, US
George W. Griesgraber - Eagan MN, US
Michael E. Danielson - Saint Paul MN, US

Assignee:

COLEY PHARMACEUTICAL GROUP, INC. - WELLESLEY MA

International Classification:

A61K 31/4375
A61K 31/437
A61P 35/00
A61P 31/12

US Classification:

514293, 514303

Abstract:

A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.

US Patent:

20090075980, Mar 19, 2009

Filed:

Mar 31, 2006

Appl. No.:

11/887496

Inventors:

David S. Hays - Woodbury MN, US
Michael E. Danielson - Saint Paul MN, US
John F. Gerster - Saint Paul MN, US
Shri Niwas - Maple Grove MN, US
Ryan B. Prince - St. Paul MN, US
Tushar A. Kshirsagar - Woodbury MN, US
Philip D. Heppner - Forest Lake MN, US
William H. Moser - St. Paul MN, US
Joan T. Moseman - Saint Paul MN, US
Matthew R. Radmer - North Robbinsdale MN, US
Maureen A. Kavanagh - Saint Paul MN, US
Sarah A. Strong - Saint Paul MN, US
Jason D. Bonk - Hudson WI, US

Assignee:

Coley Pharmaceutical Group, Inc. - Wellesley MA

International Classification:

A61K 31/473
C07D 471/04
C07D 403/14
C07D 413/14
A61K 31/5377
A61K 31/55
A61P 35/00
A61K 31/5513
A61K 31/541
A61K 31/496
C07D 417/14
C07D 243/14

US Classification:

51421707, 546 82, 544361, 544126, 544 60, 540597, 540575, 514293, 51425303, 5142328, 5142285, 514218

Abstract:

Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

US Patent:

20090318435, Dec 24, 2009

Filed:

Jun 8, 2009

Appl. No.:

12/480471

Inventors:

David S. Hays - Woodbury MN, US
Michael E. Danielson - Saint Paul MN, US
John F. Gerster - Woodbury MN, US
Shri Niwas - Maple Grove MN, US
Ryan B. Prince - St. Paul MN, US
Tushar A. Kshirsagar - Woodbury MN, US
Philip D. Heppner - Forest Lake MN, US
William H. Moser - St. Paul MN, US
Joan T. Moseman - Lake Elmo MN, US
Matthew R. Radmer - North Robbinsdale MN, US
Maureen A. Kavanagh - Stanchfield MN, US
Sarah A. Strong - Louisville CO, US
Jason D. Bonk - Hudson WI, US

International Classification:

A61K 31/5377
C07D 413/14
C07D 471/14
C07D 471/04
A61K 31/437
A61P 37/04

US Classification:

5142328, 544131, 546 82, 546 84, 514293

Abstract:

Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.