Michael L Dean

US Patent:

8470888, Jun 25, 2013

Filed:

Dec 29, 2008

Appl. No.:

12/811144

Inventors:

Curtis J. Henrich - Rockville MD, US
Heidi R. Bokesch - Frederick MD, US
Laura K. Cartner - Middletown MD, US
Richard W. Fuller - Fairfield PA, US
Kirk R. Gustafson - Frederick MD, US
Kentaro Takada - Yokohama, JP
James B. McMahon - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC

International Classification:

A61K 31/12
C07C 59/86

US Classification:

514679, 562459

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R, R, R, X, X, X, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

US Patent:

8591244, Nov 26, 2013

Filed:

Jul 8, 2011

Appl. No.:

13/179158

Inventors:

Charles Thomas - Athens PA, US
Michael Dean - Waverly NY, US
Roger Phillips - Horseheads NY, US
Allen L. Malloy - Elmira Heights NY, US

Assignee:

PPC Broadband, Inc. - East Syracuse NY

International Classification:

H01R 4/38

US Classification:

439321, 439578

Abstract:

One embodiment relates to a cable connector. The cable connector includes a body having a forward end and a rearward end opposite the forward end, a post disposed at least partially within the body, a fastener coupled to the forward end of the body, and a compressible member disposed on an outer surface of the body. The post includes a flange portion extending radially from a forward end of the post. The fastener is axially movable between a forward position and a rearward position, and wherein the fastener comprises an interior surface configured to contact the flange portion of the post when the fastener is in the forward position. The compressible member is configured to force the fastener toward the forward position such that the interior surface of the fastener provides a continuous pressure against the flange of the post when the fastener is in the forward position.

US Patent:

20100267652, Oct 21, 2010

Filed:

Nov 5, 2008

Appl. No.:

12/742039

Inventors:

Curtis J. Henrich - Rockville MD, US
Heidi R. Bokesch - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US
James B. McMahon - Frederick MD, US

International Classification:

A61K 31/7042
A61K 31/4985
A61K 31/519
A61K 31/4439
A61K 31/40
A61K 31/295
A61P 35/04

US Classification:

514 26, 514250, 5142621, 514341, 514418, 514501

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.

US Patent:

20110117777, May 19, 2011

Filed:

Oct 27, 2010

Appl. No.:

12/913068

Inventors:

Charles Thomas - Athens PA, US
Michael Dean - Waverly NY, US
Timothy Noel Tremba - Cayuta NY, US

Assignee:

THOMAS & BETTS INTERNATIONAL, INC. - Wilmington DE

International Classification:

H01R 9/05

US Classification:

439578

Abstract:

A coaxial cable connector may include a connector body having a forward end and a rearward cable receiving end for receiving a cable, a nut rotatably coupled to the forward end of the connector body, and an annular post disposed within the connector body, the annular post including an inner chamber extending axially therethrough and a first barb and a second barb. The cable connector may also include a locking sleeve including a chamber extending therethrough, a first end coupled to the connector body, a second end for receiving the cable, and at least one tooth. The locking sleeve may be configured so that when the locking sleeve is moved axially into the connector body, the at least one tooth is configured to compress the cable between the first barb and the second barb.

US Patent:

59045965, May 18, 1999

Filed:

Jul 14, 1997

Appl. No.:

8/891892

Inventors:

Gary A. Knaus - Horseheads NY
Andrew J. Kempf - Horseheads NY
Ronald P. Locati - Elmira NY
Michael R. Dean - Waverly NY

Assignee:

Thomas & Betts International, Inc. - Sparks NV

International Classification:

H01R13/66

US Classification:

439620

Abstract:

The present invention comprises a terminator which features an internal termination resistor and capacitor mounted on a substrate which is in electrical and mechanical communication with a center terminal pin at one end, and the connector body at the other end. The body of the terminator is grounded via the connection of the terminator to a cooperating connector. The present invention includes a support insulator which protects the internal components of the terminator by preventing transmission of tensile, torsional, and bending stresses through the terminal into the termination chip assembly. The stresses are absorbed by means of a supportive insulator which frictionally supports a textured section of the center terminal within the terminator. The stresses typically occur during installation or removal of the terminator to or from a connector. With the present invention it is possible to twist and bend the metal terminal of the terminator to the point of fracture without damaging the termination chip.