Michael H Dean

Address:

6911A N Brevard Ave, Tampa, FL 33604

VIN:

1FTRF12207NA15539

Make:

FORD

Model:

F-150

Year:

2007

US Patent:

8470888, Jun 25, 2013

Filed:

Dec 29, 2008

Appl. No.:

12/811144

Inventors:

Curtis J. Henrich - Rockville MD, US
Heidi R. Bokesch - Frederick MD, US
Laura K. Cartner - Middletown MD, US
Richard W. Fuller - Fairfield PA, US
Kirk R. Gustafson - Frederick MD, US
Kentaro Takada - Yokohama, JP
James B. McMahon - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC

International Classification:

A61K 31/12
C07C 59/86

US Classification:

514679, 562459

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R, R, R, X, X, X, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

US Patent:

20050160549, Jul 28, 2005

Filed:

Mar 23, 2005

Appl. No.:

11/087887

Inventors:

Michael Dean - New York NY, US

Assignee:

Saratoga Hotel Group, LLC - Saratoga Springs NY

International Classification:

A47L023/22

US Classification:

015215000

Abstract:

A floor mat system for placement directly near an entryway to permit the disinfecting and cleaning of shoe soles and all other surfaces contacting directly with the fibers of the mat. The floor mat system consists of a frame structure either mechanical or rubberized in construction. The top portion being of a carpet type fiber construction, with a hollow center portion and rubberized non-skid backing against the floor and sides. The hollow center portion of the system may be enclosed and a microbicidal component introduced to the carpet fiber portion in a capillary action.

US Patent:

20100267652, Oct 21, 2010

Filed:

Nov 5, 2008

Appl. No.:

12/742039

Inventors:

Curtis J. Henrich - Rockville MD, US
Heidi R. Bokesch - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US
James B. McMahon - Frederick MD, US

International Classification:

A61K 31/7042
A61K 31/4985
A61K 31/519
A61K 31/4439
A61K 31/40
A61K 31/295
A61P 35/04

US Classification:

514 26, 514250, 5142621, 514341, 514418, 514501

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.