Michael J Doherty

US Patent:

20230126208, Apr 27, 2023

Filed:

Dec 15, 2022

Appl. No.:

18/066945

Inventors:

- Basel, CH
Joey Roger THOMAS - Clayton NC, US
Jon LENN - Durham NC, US
Leandro SANTOS - King of Prussia PA, US
Justin WHITEMAN - Raleigh NC, US
Michael Quinn DOHERTY - Hillsborough NC, US
Mary BEDARD - King of Prussia PA, US
Piyush JAIN - Chester Springs PA, US

Assignee:

Dermavant Sciences GmbH - Basel

International Classification:

A61K 31/05
A61K 9/00
A61K 9/107
A61K 47/26
A61K 47/06
A61K 47/14
A61K 47/10
A61K 9/06
A61K 9/113

Abstract:

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

US Patent:

20230093954, Mar 30, 2023

Filed:

Nov 23, 2022

Appl. No.:

18/058306

Inventors:

- Research Triangle Park NC, US
Michael Quinn Doherty - Hillsborough NC, US

International Classification:

C12N 1/02

Abstract:

Described herein are isolated cell culture components such as, e.g., biologics and/or lipids, and methods for isolating cell culture components from a liquid cell culture medium. Methods of the present invention may include contacting a dehydration composition and a liquid cell culture medium comprising a target component to form a mixture; forming an at least partially dehydrated component in the mixture; and separating the at least partially dehydrated component from the mixture, thereby providing an isolated component. In some embodiments, the isolated component comprises the at least partially dehydrated component. In some embodiments, the isolated component is present in a composition (e.g., liquid phase) separated from the at least partially dehydrated component.

US Patent:

20200101027, Apr 2, 2020

Filed:

Sep 30, 2019

Appl. No.:

16/587833

Inventors:

- Basel, CH
Joey Roger THOMAS - Clayton NC, US
Jon LENN - Durham NC, US
Leandro SANTOS - King of Prussia PA, US
Justin WHITEMAN - Raleigh NC, US
Michael DOHERTY - Hillsborough NC, US
Mary BEDARD - King of Prussia PA, US
Piyush JAIN - Chester Springs PA, US

Assignee:

Dermavant Sciences GmbH - Basel

International Classification:

A61K 31/05
A61K 9/00
A61K 9/107
A61K 9/113
A61K 9/06
A61K 47/06
A61K 47/08
A61K 47/10
A61K 47/22
A61K 47/44

Abstract:

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

US Patent:

20190192445, Jun 27, 2019

Filed:

Dec 21, 2018

Appl. No.:

16/229080

Inventors:

- Basel, CH
Joey Roger THOMAS - Clayton NC, US
Jon LENN - Durham NC, US
Leandro SANTOS - King of Prussia PA, US
Justin WHITEMAN - Raleigh NC, US
Michael Quinn DOHERTY - Hillsborough NC, US
Mary BEDARD - Research Triangle Park NC, US
Piyush JAIN - Chester Springs PA, US

International Classification:

A61K 31/05
A61K 47/44
A61K 47/22
A61K 9/06
A61K 47/06
A61K 9/00
A61K 47/10
A61K 9/113
A61K 9/107
A61K 47/08

Abstract:

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

US Patent:

20190192446, Jun 27, 2019

Filed:

Dec 21, 2018

Appl. No.:

16/229145

Inventors:

- Basel, CH
Joey Roger THOMAS - Clayton NC, US
Jon LENN - Durham NC, US
Leandro SANTOS - King of Prussia PA, US
Justin WHITEMAN - Raleigh NC, US
Michael Quinn DOHERTY - Hillsborough NC, US
Mary BEDARD - King of Prussia NC, US
Piyush JAIN - Chester Springs PA, US

International Classification:

A61K 31/05
A61K 47/44
A61K 47/22
A61K 9/06
A61K 47/06
A61K 9/00
A61K 47/10
A61K 9/113
A61K 9/107
A61K 47/08

Abstract:

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

US Patent:

20190151255, May 23, 2019

Filed:

Jan 23, 2019

Appl. No.:

16/255121

Inventors:

- Basel, CH
Joey Roger THOMAS - Clayton NC, US
Jon LENN - Durham NC, US
Leandro SANTOS - King of Prussia PA, US
Justin WHITEMAN - Raleigh NC, US
Michael Quinn DOHERTY - Hillsborough NC, US
Mary BEDARD - King of Prussia NC, US
Piyush JAIN - Chester Springs PA, US

International Classification:

A61K 31/05
A61K 47/44
A61K 47/22
A61K 9/06
A61K 47/06
A61K 9/00
A61K 47/10
A61K 9/113
A61K 9/107
A61K 47/08

Abstract:

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

US Patent:

20180064656, Mar 8, 2018

Filed:

Nov 9, 2017

Appl. No.:

15/807682

Inventors:

- Brentford, GB
Joey Roger Thomas - Research Triangle Park NC, US
Jon Lenn - Research Triangle Park PA, US
Leandro Santos - Research Triangle Park NC, US
Justin Whiteman - Raleigh NC, US
Michael Quinn Doherty - Research Triangle Park NC, US
Mary Bedard - Research Triangle Park NC, US

International Classification:

A61K 31/05
A61K 9/00
A61K 9/107
A61K 9/06
A61K 47/06
A61K 47/14
A61K 47/10
A61K 47/26

Abstract:

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.