Michael D Feld

US Patent:

6404497, Jun 11, 2002

Filed:

Jan 25, 1999

Appl. No.:

09/237153

Inventors:

Vadim Backman - Cambridge MA
Rajan Gurjar - Cambridge MA
Irving Itzkan - Boston MA
Lev Perelman - Brookline MA
Michael S. Feld - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01J 400

US Classification:

356369

Abstract:

The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of backscattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.

US Patent:

6537211, Mar 25, 2003

Filed:

Jan 26, 1999

Appl. No.:

09/238664

Inventors:

Thomas D. Wang - Boston MA
Michael S. Feld - Newton MA
Yang Wang - Blue Bell PA
Jacques Van Dam - Brookline MA
Stephen F. Fulghum - Marblehead MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61B 106

US Classification:

600178, 600160, 600476

Abstract:

The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. The imaging system also includes an electronic controller that actuates the illumination of the system by switching current through the first light source between a first illumination level and a second illumination level such that the tissue is illuminated at the first or second illumination level. An imaging device mounted at the distal end of the device is used to collect both images.

US Patent:

6611339, Aug 26, 2003

Filed:

Jun 9, 2000

Appl. No.:

09/591297

Inventors:

Changhuei Yang - Cambridge MA
Adam Wax - Boston MA
Michael S. Feld - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01B 902

US Classification:

356485, 356479

Abstract:

Radiation that propagates undeflected through a turbid medium, undergoes a small change in phase velocity due to its wave nature. This change can be measured using a differential phase optical interferometer. Ballistic propagation can be classified into three regimes: For scatterers small compared to the wavelength, the turbid medium acts as a bulk medium; for large scatterers, phase velocity is independent of turbidity; and in the intermediate regime the phase velocity is strongly dependent on scatterer radius. In particular, for scatterers having intermediate size a phase velocity increase and negative dispersion is observed by adding positive dispersion scatterers of higher refractive index. These measurements are made using the phase difference between fundamental and harmonic light and can be used to provide diagnostic information and images of tissue or biological fluids.

US Patent:

6624890, Sep 23, 2003

Filed:

May 24, 2002

Appl. No.:

10/155194

Inventors:

Vadim Backman - Cambridge MA
Ramachandra R. Dasari - Lexington MA
Rajan Gurjar - Cambridge MA
Irving Itzkan - Boston MA
Lev Perelman - Brookline MA
Michael S. Feld - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01J 400

US Classification:

356369

Abstract:

The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of back-scattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.

US Patent:

6697652, Feb 24, 2004

Filed:

Jan 19, 2001

Appl. No.:

09/766879

Inventors:

Irene Georgakoudi - Waltham MA
Vadim Backman - Cambridge MA
Michael S. Feld - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61B 500

US Classification:

600310, 600476, 600477, 600478, 600407, 356342

Abstract:

Preferred embodiments of the present invention utilize a plurality of spectroscopic techniques to measure characteristics of tissue useful in the diagnosis of disease. Fluorescence, reflectance and light scattered spectra can be measured and processed to determine the size, distribution and/or composition of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.

US Patent:

6697665, Feb 24, 2004

Filed:

Aug 11, 1994

Appl. No.:

08/288990

Inventors:

Richard P. Rava - Waltham MA
Joseph J. Baraga - Somerville MA
Michael S. Feld - Waban MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61B 600

US Classification:

600475

Abstract:

Systems and methods for spectroscopic diagnosis and treatment are employed which utilize molecular spectroscopy to accurately diagnose the condition of tissue. Infrared Raman spectrscopy and infrared attenuated total reflectance measurements are performed utilizing a laser radiation source and a fourier transform spectrometer. Information acquired and analyzed in accordance with the invention provides accurate details of biochemical composition and pathologic condition.

US Patent:

6847456, Jan 25, 2005

Filed:

Apr 27, 2001

Appl. No.:

09/844286

Inventors:

Changhuei Yang - Cambridge MA, US
Adam P. Wax - Boston MA, US
Lev T. Perelman - Brookline MA, US
Ramachandra R. Dasari - Lexington MA, US
Michael S. Feld - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01B 902

US Classification:

356489, 356511

Abstract:

The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.

US Patent:

6912412, Jun 28, 2005

Filed:

Jan 18, 2002

Appl. No.:

10/052583

Inventors:

Irene Georgakoudi - Acton MA, US
Michael S. Feld - Newton MA, US
Qingguo Zhang - Medford MA, US
Markus G. Mueller - Erlenbach, DE

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61B005/00

US Classification:

600310, 600473, 600476, 600477, 600478, 600407, 356342

Abstract:

The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.