Michael K Fiske

US Patent:

6753417, Jun 22, 2004

Filed:

Sep 12, 2001

Appl. No.:

09/952267

Inventors:

Eric J. Hansen - Plano TX
Christoph Aebi - Gasel, CH
Leslie D. Cope - Mesquite TX
Isobel Maciver - Cottage Grove WI
Michael J. Fiske - Rochester NY
Ross A. Fredenburg - Rochester NY

Assignee:

Board of Regents, The University of Texas System - Austin TX
American Cyanamid Company - Madison NJ

International Classification:

C07H 2104

US Classification:

536 231, 536 237, 536 243

Abstract:

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i. e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of are disclosed.

US Patent:

7288646, Oct 30, 2007

Filed:

Jun 21, 2004

Appl. No.:

10/872768

Inventors:

Eric J. Hansen - Plano TX, US
Christoph Aebi - Gaselstrasse, CH
Leslie D. Cope - Mesquite TX, US
Isobel Maciver - Cottage Grove WI, US
Michael J. Fiske - Rochester NY, US
Ross A. Fredenburg - Rochester NY, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07H 21/04

US Classification:

536 237, 536 231, 536 243

Abstract:

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (ie. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of are disclosed.

US Patent:

7344724, Mar 18, 2008

Filed:

Jun 21, 2004

Appl. No.:

10/872769

Inventors:

Eric J. Hansen - Plano TX, US
Christoph Aebi - Gasel, CH
Leslie D. Cope - Mesquite TX, US
Isobel Maciver - Cottage Grove WI, US
Michael J. Fiske - Rochester NY, US
Ross A. Fredenburg - Rochester NY, US

Assignee:

Board of Regents, The University of Texas System - Austin TX
Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 39/02

US Classification:

4242511, 4242341, 4241851, 4241901, 530300, 530350

Abstract:

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i. e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of are disclosed.

US Patent:

7569683, Aug 4, 2009

Filed:

Mar 7, 2008

Appl. No.:

12/044818

Inventors:

Eric J. Hansen - Plano TX, US
Christoph Aebi - Gasel, CH
Leslie D. Cope - Mesquite TX, US
Isobel Maciver - Cottage Grove WI, US
Michael J. Fiske - Rochester NY, US
Ross A. Fredenburg - Rochester NY, US

Assignee:

Board of Regents, The University of Texas System - Austin TX
Wyeth Holding Corporation - Wayne NJ

International Classification:

C07H 21/04

US Classification:

536 237, 536 231, 536 243

Abstract:

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i. e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of are disclosed.

US Patent:

7576194, Aug 18, 2009

Filed:

Mar 7, 2008

Appl. No.:

12/044805

Inventors:

Eric J. Hansen - Plano TX, US
Christoph Aebi - Gaselstrasse, CH
Leslie D. Cope - Mesquite TX, US
Isobel Maciver - Cottage Grove WI, US
Michael J. Fiske - Rochester NY, US
Ross A. Fredenburg - Rochester NY, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07H 21/04

US Classification:

536 237, 536 231, 536 243

Abstract:

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i. e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of are disclosed.

US Patent:

63101904, Oct 30, 2001

Filed:

Jun 21, 1999

Appl. No.:

9/336447

Inventors:

Eric J. Hansen - Plano TX
Christoph Aebi - Gasel, CH
Leslie D. Cope - Mesquite TX
Isobel Maciver - Cottage Grove WI
Michael J. Fiske - Rochester NY
Ross A. Fredenburg - Rochester NY

Assignee:

Board of Regents, The University of Texas - Austin TX
American Cyanamid - Madison NJ

International Classification:

C07H 2104

US Classification:

536 231

Abstract:

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i. e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.