Michael J Fitzgerald

US Patent:

6495314, Dec 17, 2002

Filed:

Jun 19, 1998

Appl. No.:

09/043877

Inventors:

Stephen B. H. Kent - San Francisco CA
Tom W. Muir - New York NY
Philip E. Dawson - San Diego CA
Michael C. Fitzgerald - San Diego CA

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C07K 104

US Classification:

435 4, 435 71, 435 19, 435 23, 435 24, 435106, 435DIG 15, 530300, 530344, 530350

Abstract:

A protein signature analysis is obtained using a peptide ladder library. The molecular signature of a protein is defined to be that subsequence of amino acid positions within the protein which are essential for the protein to bind to a target molecule. The molecular signature may be determined by screening a peptide ladder library which corresponds to the protein against the target molecule. The peptide ladder library is a library of m peptides wherein each peptide has an amino acid sequence of length m corresponding to an amino acid sequence of the protein, with one exception, viz. peptide has a substitute amino acid at position and the substitute amino acid is attached by a labile bond to its neighboring amino acid. Screening the peptide ladder library against the target molecule results in a division of the original mixture into a positive (functional) pool and a negative (non-functional) pool. The pools are separated and subjected to cleavage to obtain cleavage products.

US Patent:

20020128215, Sep 12, 2002

Filed:

Feb 2, 2001

Appl. No.:

09/776407

Inventors:

Hans-Ulrich Thomann - Lexington MA, US
Kristen Wall - Hingham MA, US
Michael Fitzgerald - Waltham MA, US

International Classification:

A61K048/00
C12Q001/68
C07H021/04
C12N009/00
C12N005/06

US Classification:

514/044000, 435/183000, 435/325000, 435/320100, 536/023200, 435/006000

Abstract:

This invention relates to novel polymorphisms of the NAT-2 gene which can be involved in drug metabolism and various disorders.

US Patent:

20030082550, May 1, 2003

Filed:

Sep 7, 2001

Appl. No.:

09/949293

Inventors:

Hans-Ulrich Thomann - Lexington MA, US
Kristen Diamond - Duxbury MA, US
Michael FitzGerald - Waltham MA, US

International Classification:

C12Q001/68
C12N009/02
C07H021/04

US Classification:

435/006000, 435/189000, 536/023200

Abstract:

This invention relates to isolated nucleic acids comprising single nucleotide polymorphisms of the human COX-2 gene and the proteins encoded by these nucleotides. The invention also relates to pharmacogenomics. The invention provides methods of using the polymorphisms in diagnostics and therapeutics.

US Patent:

20030211504, Nov 13, 2003

Filed:

Oct 9, 2002

Appl. No.:

10/268058

Inventors:

Kim Fechtel - Arlington MA, US
Shashi Prabhakar - Burlington MA, US
Hui Huang - Newton MA, US
Michael FitzGerald - Waltham MA, US
Joann Prescott-Roy - Concord MA, US
Michelle Runge - Bedford NH, US
Huajun Wang - Newton MA, US
Rene Gibson - Bedford MA, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The invention provides an automated method of identifying a plurality of different polymorphisms within two or more related nucleic acid sequences. The method consists of: (a) obtaining a data set comprising a nucleic acid sequence assembly and a plurality of sequence characteristic parameters associated with said assembly; (b) indexing said nucleic acid assembly and said plurality of sequence characteristic parameters in a database; (c) selecting a region of said nucleic acid assembly having sequence characteristic parameters indicative of a polymorphic sequence, and (d) displaying two or more nucleic acid sequences of said region, said two or more sequences identifying different polymorphisms within said nucleic acid assembly. Also provided is a method of identifying a nucleic acid containing an indel region within a set of related nucleic acid sequences. The method consists of comprising: (a) dentifying a nucleic acid within two or more related nucleic acid sequences suspected of containing an indel region, said nucleic acid containing one or more regions having a plurality of polymorphisms, and (b) determining the occurrence of two or more criteria indicating the presence of an indel region associated with said one or more regions having a plurality of polymorphisms, said occurrence characterizing said nucleic acid as containing an indel region. Further provides is a method of determining the sequence of an allele containing an indel region within a set of related nucleic acid sequences. The method consists of comprising: (a) identifying a nucleic acid containing an indel region within two or more related nucleic acid sequences; (b) generating a consensus sequence within said indel region for said two or more related nucleic acid sequences; (c) identifying a matching string to said consensus sequence within at least one of said two or more related nucleic acid sequences, and (d) subtracting said consensus sequence from said two or more related nucleic acid sequences, the presence or absence of a unique sequence in one of said related nucleic acid sequences indicating the presence of an actual indel region. The invention additionally provides an automated system for identifying a plurality of different polymorphisms within two or more related nucleic acid sequences. The system consists of: (a) a sample submission module capable of transmitting data; (b) a core statistics loading and post processing module containing sequence characteristic parameters; (c) an assembly module capable constructing sequence assemblies from sequence database extracted data; (d) a SNP prospector module capable of identifying polymorphisms; (e) a polymorphism loader submodule capable of parsing polymorphic region sequence and sequence characteristic parameters from sequence assemblies; (f) a SNP database structured to contain the information produced in steps (a) through (e), and (g) an output module for display or further manipulation of specified data in step (f).

US Patent:

55919073, Jan 7, 1997

Filed:

Jul 13, 1995

Appl. No.:

8/502219

Inventors:

Peter J. Stein - Hollis NH
Armen Bahlavouni - Waltham MA
Michael G. Fitzgerald - Wilmington MA
Douglas W. Andersen - Acton MA

Assignee:

Scientific SOlutions, Inc. - Hollis NH

International Classification:

G12B 900

US Classification:

7317016

Abstract:

A sensing apparatus, for use in adverse conditions comprising a housing having an aperture formed therein. A generally spherically shaped housing, which is larger in size than the aperture, partially extends through the aperture. The generally spherically shaped housing supports a desired sensor and is supported for rotation about an axis of rotation. A drive mechanism is provided for rotating the generally spherically shaped housing to and fro about its rotational axis from a use position, in which the sensor is positioned outside the housing to obtain sensor measurements, to a retracted position in which the sensor is completely accommodated within the housing and sheltered from the elements. A peripheral scraping ring is mounted circumferentially about the aperture in close proximity to an exterior surface of the generally spherically shaped housing but spaced therefrom. The scraping ring is positioned to remove any snow, ice, rain, freezing rain, moisture, dirt, soot, or other contaminants contained on the exterior surface of the generally spherically shaped housing during rotation thereof.

US Patent:

20210136062, May 6, 2021

Filed:

Nov 4, 2019

Appl. No.:

16/673642

Inventors:

Michael Fitzgerald - Winchester MA, US

International Classification:

H04L 29/06

Abstract:

A biometric data collection and authentication system which validates the user of a dynamically generated and customizable internet form. The system may be used to generate biometric data from fingerprints, retinal scans, and voice-prints. It utilizes a client side biometric collection tool to allow verification against an existing database, or assign a unique identifier for future verification. It also has the ability to parse biometric information on to user provided or created documents.

US Patent:

20170186411, Jun 29, 2017

Filed:

Dec 21, 2016

Appl. No.:

15/386825

Inventors:

- Boston MA, US
Eric J. BROSIUS - Arlington MA, US
Paul BURROWES - Woburn MA, US
Michael FITZGERALD - Cambridge MA, US
Alexander RIGOPULOS - Belmont MA, US

International Classification:

G10H 1/00
A63F 1/04
A63F 9/24
A63F 1/00

Abstract:

The present disclosure relates to an apparatus, system, and method that allow non-musicians to compose and perform a musical composition. Although some existing electronic devices can provide a virtual environment to compose and play musical sound digitally, manipulating such a virtual environment can be difficult and may require specific software expertise, as well as knowledge of music theory. The present disclosure provides a platform that facilitates the creation of a musical composition without such software expertise or knowledge of music theory. The platform models a musical composition as a simultaneous playback of one or more musical contents. The platform allows players to control or modify one or more of the plurality of musical contents to generate or synthesize a musical composition.