Michael D Freeman

US Patent:

20140056807, Feb 27, 2014

Filed:

Aug 23, 2013

Appl. No.:

13/975059

Inventors:

Michael R. Freeman - Los Angeles CA, US
Matteo Morello - Beverly Hills CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

G01N 1/34

US Classification:

424 111, 435 71, 4242771, 4353171

Abstract:

The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.

US Patent:

50930877, Mar 3, 1992

Filed:

Feb 19, 1991

Appl. No.:

7/657416

Inventors:

Michael D. Freeman - Canoga Park CA

International Classification:

B01J 1908
B01J 1912

US Classification:

42218615

Abstract:

An apparatus for production of quantities of ozone utilizes a flow of air through an ozone chamber, wherein the ozone chamber is defined between a conductive rod and an externally positioned metallic housing. The metallic housing includes a polymeric cylindrical housing contiguous therewith and extending upwardly beyond the metallic housing. The central conductive rod includes a polymeric sheath thereabout, with a cap overlying the polymeric cylindrical housing defining the ozone chamber, with the rod in electrical communication with an outlet socket of a twelve-volt coil. The twelve-volt coil includes a positive and negative terminal, with the positive terminal including a positive twelve-volt charge directed thereto, as well as a switch positive 110 volt alternating current charge directed thereto. The negative terminal includes a negative twelve-volt connector directed from an associated battery directing the positive charge to the positive terminal, wherein the negative terminal further includes an adjustable voltage regulator directed through the negative 110 volt connection to the negative terminal of the coil.

US Patent:

20180282817, Oct 4, 2018

Filed:

Oct 5, 2016

Appl. No.:

15/764185

Inventors:

- Los Angeles CA, US
Michael FREEMAN - West Hollywood CA, US
Jayoung KIM - Beverly Hills CA, US
Beatrice KNUDSEN - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

C12Q 1/6886
A61K 33/24
A61K 31/337
A61K 31/4166
A61K 31/506
G06F 19/20

Abstract:

The invention provides various methods for classifying prostate cancers into subtypes. The classification methods may be used to diagnose or prognose prostate cancers. In one embodiment, the subtypes are PCS1, PCS2, or PCS3. In one embodiment, the PCS1 subtype is most likely to progress to metastatic disease or prostate cancer specific mortality when compared to the PCS2 subtype or PCS3 subtype. In one embodiment, the PCS1 subtype is resistant to enzalutamide.

US Patent:

20160061842, Mar 3, 2016

Filed:

Oct 14, 2015

Appl. No.:

14/883421

Inventors:

- Los Angeles CA, US
Michael R. Freeman - Los Angeles CA, US
Matteo Morello - Beverly Hills CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

G01N 33/574
C12Q 1/68
A61K 45/06

Abstract:

The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes and contents of the large oncosomes in a subject in need thereof. Also provided herein are methods for treating cancer metastasis by specifically targeting contents of the large oncosomes.

US Patent:

20150037814, Feb 5, 2015

Filed:

Mar 6, 2014

Appl. No.:

14/199219

Inventors:

- Boston MA, US
Michael R. Freeman - Los Angeles CA, US
Dmitri Wiederschain - Brookline MA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

G01N 33/573
G01N 33/574

US Classification:

435 74

Abstract:

Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.

US Patent:

20140178893, Jun 26, 2014

Filed:

Jul 16, 2013

Appl. No.:

13/942783

Inventors:

- Boston MA, US
Michael R. Freeman - Los Angeles CA, US
Dmitri Wiederschain - Brookline MA, US

International Classification:

G01N 33/573

US Classification:

435 74

Abstract:

Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.