Michael G Garguilo

US Patent:

6344145, Feb 5, 2002

Filed:

Apr 10, 2000

Appl. No.:

09/546290

Inventors:

Michael G. Garguilo - Livermore CA
Phillip H. Paul - Livermore CA
David J. Rakestraw - Fremont CA

Assignee:

Sandia Corporation - Livermore CA

International Classification:

B01D 1508

US Classification:

210635, 210656, 2101982, 204455, 204605

Abstract:

Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated, thereby providing for a significant improvement in resolution and more accurate detection and analysis.

US Patent:

6428666, Aug 6, 2002

Filed:

Feb 22, 1999

Appl. No.:

09/256586

Inventors:

Anup K. Singh - Berkeley CA
David W. Neyer - Castro Valley CA
Joseph S. Schoeniger - Oakland CA
Michael G. Garguilo - Livermore CA

Assignee:

Sandia National Laboratories - Livermore CA

International Classification:

G01N 2726

US Classification:

204450, 204451, 204518, 204540, 204542, 204554, 204600, 204624, 204601, 210748

Abstract:

A method for separating and concentrating charged species from uncharged or neutral species regardless of size differential. The method uses reversible electric field induced retention of charged species, that can include molecules and molecular aggregates such as dimers, polymers, multimers, colloids, micelles, and liposomes, in volumes and on surfaces of porous materials. The retained charged species are subsequently quantitatively removed from the porous material by a pressure driven flow that passes through the retention volume and is independent of direction thus, a multi-directional flow field is not required. Uncharged species pass through the system unimpeded thus effecting a complete separation of charged and uncharged species and making possible concentration factors greater than 1000-fold.

US Patent:

60687673, May 30, 2000

Filed:

Oct 29, 1998

Appl. No.:

9/182124

Inventors:

Michael G. Garguilo - Livermore CA
Phillip H. Paul - Livermore CA
David J. Rakestraw - Fremont CA

Assignee:

Sandia Corporation - Livermore CA

International Classification:

B01D 1508

US Classification:

2101982

Abstract:

Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated, thereby providing for a significant improvement in resolution and more accurate detection and analysis.