Michael A Goodman

US Patent:

7748657, Jul 6, 2010

Filed:

Aug 7, 2008

Appl. No.:

12/221991

Inventors:

Michael N. Goodman - Sacramento CA, US

International Classification:

A01K 89/01

US Classification:

242323, 242250

Abstract:

The tool is coupleable to an arm of a reel of a fishing rod. The tool includes a shank at one end removably coupleable to a rotating drive. A cylinder is oriented opposite the shank with a hollow bore extending into a free end of the cylinder. A slot extends through a wall of the cylinder with an axial leg adjacent an entry of the slot and a circumferential leg spaced from the axial leg by a bend. The arm passes into the bore with portions of the arm first passing through the axial leg and then into the circumferential leg. The arm is thus securely held within the slot of the cylinder and the arm rotates when the cylinder is caused to rotate along with the shank when the shank is coupled to the drive and the drive is rotated, and line is drawn onto the reel.

US Patent:

54766591, Dec 19, 1995

Filed:

Nov 12, 1993

Appl. No.:

8/151142

Inventors:

Michael G. Goodman - Rancho Santa Fe CA
Lawrence D. Piro - La Jolla CA

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 3939
A61K 3170
C12N 506
C12N 508

US Classification:

4242781

Abstract:

Processes for the killing of cancerous B cells, and particularly chronic lymphocytic leukemia (CLL) cells are disclosed. In one process, cancerous B cells that do not proliferate when contacted with an immune response-enhancing agent are contacted with an amount of such an agent sufficient to cause peripheral CLL cells to undergo blast transformation and proliferation. The contacted cells are then maintained for a time period sufficient for them to die from that contact. Further contacting of those cells with a cytotoxic amount of an anti-cancer drug or cytotoxic conjugate enhances the death of those cancer cells. In another process, peripheral CLL cells that proliferate on contact with an immune response-enhancing-agent are contacted with a proliferation-inducing amount of such an agent. The contacted cells are maintained for a time period sufficient to undergo blast transformation and proliferation, and the blasts are then contacted with a cytotoxic amount of an anti-cancer drug or cytotoxic conjugate and maintained.

US Patent:

53170130, May 31, 1994

Filed:

Sep 15, 1992

Appl. No.:

7/945215

Inventors:

Michael G. Goodman - Carlsbad CA
William O. Weigle - Del Mar CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

A61K 3170
A61K 4505
C07K 1300

US Classification:

514 45

Abstract:

Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.

US Patent:

51661411, Nov 24, 1992

Filed:

May 24, 1988

Appl. No.:

7/198141

Inventors:

Michael G. Goodman - Rancho Santa Fe CA
Edward P. Gamson - Highland Park IL

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

A61K 3170
C07H 19167
C07H 19173

US Classification:

514 45

Abstract:

An immune response-enhancing guanosine analog derivative having a structure that conforms to the formula ##STR1## wherein Z is oxygen (O) or sulfur (S); X is oxygen (O), sulfur (S) selenium (Se) or cyanimino (NCN); and R. sub. 1 is an aldoglycoside is disclosed. Also disclosed are a composition containing the guanosine analog derivative as active ingredient and a method of using the composition for immunostimulation.

US Patent:

49487302, Aug 14, 1990

Filed:

Jun 6, 1989

Appl. No.:

7/361974

Inventors:

Michael G. Goodman - Carlsbad CA
William O. Weigle - Del Mar CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

C12P 2100
A61K 3766
C07K 1526

US Classification:

435 705

Abstract:

Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged funtionality, while the 8-substituent has an electron withdrawing inductive effector greater than that of hydrogen and contains fewer than about 15 atoms. Anmimal cellular responses are modulated by contacting the cells with a composition of this invention.

US Patent:

48494119, Jul 18, 1989

Filed:

Feb 13, 1987

Appl. No.:

7/014618

Inventors:

Michael G. Goodman - Carlsbad CA
William O. Weigle - Del Mar CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

A61K 3170
C12N 500

US Classification:

514 45

Abstract:

Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.

US Patent:

50118285, Apr 30, 1991

Filed:

May 5, 1988

Appl. No.:

7/190697

Inventors:

Michael Goodman - Rancho Santa Fe CA
William Weigle - Del Mar CA
Stanley Bell - Narberth PA
Robert Chen - Belle Mead NJ
Roland K. Robins - Irvine CA
William J. Hennen - Bryan TX

International Classification:

A61K 3170
C08B 3100

US Classification:

514 45

Abstract:

7,8-Disubstituted guanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are hydrocarbyl radicals having a length greater than ethyl and less than about decyl. 8-Substituents are. dbd. O,. dbd. S,. dbd. Se and. dbd. NCN. Compositions and methods of use are also disclosed.

US Patent:

47466510, May 24, 1988

Filed:

Nov 15, 1985

Appl. No.:

6/798629

Inventors:

Michael G. Goodman - Rancho Santa Fe CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

A61K 3170

US Classification:

514 45

Abstract:

An antimicrobial composition and its method of use are disclosed. The composition contains an in vivo effective amount of an antibiotic and a potentiating amount of an immune response-enhancing agent. The immune response-enhancing agent corresponds in structure to a formula selected from ##STR1## where X is O or S; Z is N--R. sub. 2, O or S; R. sub. 1, R. sub. 2 and R. sub. 3 are substituted groups; and R. sub. 4 is an aldoglycosidyl radical.