Michael Lee Greene

US Patent:

20130203083, Aug 8, 2013

Filed:

Feb 10, 2011

Appl. No.:

13/578294

Inventors:

Lawreen Connors - Woburn MA, US
Michael J. Greene - Allston MA, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY - Boston MA

International Classification:

G01N 33/68

US Classification:

435 792, 436501, 435 71, 422 69, 4352872

Abstract:

The present invention relates generally to diagnostic methods, systems, assays and kits for identification of subjects with cardiac amyloid deposits, where a low level of clusterin protein in a peripheral fluid sample, e.g., a serum sample from the subject, indicates the subject likely has cardiac amyloid deposits. Other aspects relate to methods of treatment of diseases or disorders characterized by cardiac amyloid deposits and transthyretin (TTR) amyloidosis, and more particularly to methods of treatment of cardiac-related amyloidosis and cardiac amyloid deposits in subjects with familial transthyretin (TTR), senile systemic amyloidosis (SSA), or familial amyloidodic polyneuropathy (FAP), or immunoglobulin light chain (AL) amyloidosis. Other aspects relate to methods and compositions comprising clusterin (CLU) or a clusterin agent (e.g. an agonist of clusterin activity or a biologically active fragment or derivative thereof), and their use in methods to treat a disease or disorder characterized by transthyretin (TTR) amyloidosis, e.g. senile systemic amyloidosis (SSA) or familial amyloidodic polyneuropathy (FAP), and their use in methods to treat amyloidotic cardiomyopathy associated with transthyretin (TTR) amyloidosis.

US Patent:

20140058763, Feb 27, 2014

Filed:

Jul 24, 2013

Appl. No.:

13/987437

Inventors:

Michael F. Greene - Boston MA, US
John R. Lucker - Simsbury CT, US
Steven E. Ellis - Linthicum Heights MD, US
James C. Guszcza - Santa Monica CA, US
Steven L. Berman - Havertown PA, US
Amin Torabkhani - New York NY, US

International Classification:

G06Q 40/08

US Classification:

705 4

Abstract:

An unsupervised statistical analytics approach to detecting fraud utilizes cluster analysis to identify specific clusters of claims or transactions for additional investigation, or utilizes association rules as tripwires to identify outliers. The clusters or sets of rules define a “normal” profile for the claims or transactions used to filter out normal claims, leaving “not normal” claims for potential investigation. To generate clusters or association rules, data relating to a sample set of claims or transactions may be obtained, and a set of variables used to discover patterns in the data that indicate a normal profile. New claims may be filtered, and not normal claims analyzed further. Alternatively, patterns for both a normal profile and an anomalous profile may be discovered, and a new claim filtered by the normal filter. If the claim is “not normal” it may be further filtered to detect potential fraud.

US Patent:

20220364055, Nov 17, 2022

Filed:

Aug 30, 2019

Appl. No.:

17/271430

Inventors:

- Basel, CH
Michael R. Greene - Groton MA, US
Jennifer Brogdon - Sudbury MA, US
Boris Engels - Arlington MA, US
Glenn Dranoff - Sudbury MA, US
Olja Kodrasi - Quincy MA, US
Hyungwook Lim - Cambridge MA, US
Akash Sohoni - Cambridge MA, US
Elizabeth Dorothy Pratico - East Boston MA, US
Anniesha Hack - East Hanover NJ, US
Aida Abujoub - Winchester MA, US
Tony Fleming - Stow MA, US
Lu Huang - West Roxbury MA, US
Connie Hong - Somerville MA, US
John Blankenship - Acton MA, US
Brian Holmberg - Somerville MA, US
Chonghui Zhang - Cambridge MA, US
Dexiu Bu - Melrose MA, US
Andrew Price - Cambridge MA, US
Xu Zhu - Cambridge MA, US
Andrew Stein - Cambridge MA, US
Attilio Bondanza - Basel, CH

International Classification:

C12N 5/0783
A61K 35/17
A61K 31/519
A61K 38/20
C07K 16/28
C07K 14/705

Abstract:

The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.

US Patent:

20210220404, Jul 22, 2021

Filed:

Nov 25, 2020

Appl. No.:

17/104983

Inventors:

Michael R. Greene - Cambridge MA, US
- Basel, CH
Attilio Bondanza - Basel, CH
Jennifer Brogdon - Sudbury MA, US
Dexiu Bu - Melrose MA, US
Serena De Vita - Brookline MA, US
Glenn Dranoff - Sudbury MA, US
Boris Engels - Arlington MA, US
Tony Fleming - Stow MA, US
Brian Walter Granda - Salisbury MA, US
Michael R. Greene - Groton MA, US
Carla Patricia Guimaraes - Boston MA, US
Anniesha Hack - East Hanover MA, US
Brian Holmberg - Somerville MA, US
Connie Hong - Somerville MA, US
Lu Huang - West Roxbury MA, US
Olja Kodrasi - Quincy MA, US
Joni Waiee Lam - Somerville MA, US
Hyungwook Lim - Cambridge MA, US
Elizabeth Dorothy Pratico - East Boston MA, US
Andrew Price - Cambridge MA, US
Akash Sohoni - Cambridge MA, US
Andrew Marc Stein - Cambridge MA, US
Louise Treanor - Cambridge MA, US
Chonghui Zhang - Cambridge MA, US
Xu Zhu - Cambridge MA, US

International Classification:

A61K 35/17
C07K 16/28
A61P 35/00
A61K 45/06
A61K 39/395
C07K 14/705
A61K 38/17
C12N 5/0783
C07K 14/725

Abstract:

The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

US Patent:

20200248130, Aug 6, 2020

Filed:

Jan 10, 2020

Appl. No.:

16/739573

Inventors:

- Basel, CH
- Philadelphia PA, US
Michael R. Greene - Cambridge MA, US
Lan Cao - East Hanover NJ, US

International Classification:

C12M 1/00
B03C 1/01
B03C 1/28
B03C 1/033
B03C 1/30
C12N 13/00
C12M 1/12
C07K 16/28

Abstract:

The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.

US Patent:

20190269727, Sep 5, 2019

Filed:

Dec 27, 2016

Appl. No.:

16/066788

Inventors:

Fabio Fachin - Brookline MA, US
Lan Cao - Morris Plains NJ, US
Michael R. Greene - Groton MA, US
Tatiana Golovina - Havertown PA, US
- Basel, CH
- Philadelphia PA, US

International Classification:

A61K 35/17
C07K 14/725
C12N 5/0783
C07K 1/04
A61M 1/34
A61M 1/36

Abstract:

The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.

US Patent:

20160355777, Dec 8, 2016

Filed:

Jun 3, 2016

Appl. No.:

15/172415

Inventors:

- Basel, CH
- Philadelphia PA, US
Michael R. Greene - Cambridge MA, US
Lan Cao - East Hanover NJ, US

International Classification:

C12M 1/00
C12N 13/00
C12M 1/12
C07K 16/28

Abstract:

The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.