Michael Eric Haley

US Patent:

7803946, Sep 28, 2010

Filed:

Dec 14, 2007

Appl. No.:

11/957243

Inventors:

Michael M. Haley - Eugene OR, US
Darren W. Johnson - Eugene OR, US
Orion B. Berryman - Eugene OR, US
Charles A. Johnson - Eugene OR, US
Calden N. Stimpson - Eugene OR, US

International Classification:

C07D 213/38
C07D 213/40

US Classification:

546257, 546265, 546335, 546337

Abstract:

Disclosed herein is a class of tunable phenylacetylene compounds as well as compositions and methods for their use as host compounds for ligand binding. In certain examples the hosts report binding events by exhibiting altered spectroscopic properties, such as different fluorescent emission spectra.

US Patent:

8436049, May 7, 2013

Filed:

Feb 20, 2009

Appl. No.:

12/918696

Inventors:

John Andrew Berglund - Eugene OR, US
M. Bryan Warf - Eugene OR, US
Catherine Matthys - Eugene OR, US
Michael M. Haley - Eugene OR, US
Cameron L. Hilton - Eugene OR, US

Assignee:

State of Oregon Acting By and Through the State Board of Higher Education on behalf of the University of Oregon - Eugene OR

International Classification:

A01N 37/52
A61K 31/155

US Classification:

514631, 514637

Abstract:

Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.

US Patent:

20110015396, Jan 20, 2011

Filed:

Sep 28, 2010

Appl. No.:

12/892823

Inventors:

Michael M. HALEY - Eugene OR, US
Darren W. JOHNSON - Eugene OR, US
Orion B. BERRYMAN - Eugene OR, US
Charles A. JOHNSON - Alexandria VA, US
Calden N. STIMPSON - Eugene OR, US

Assignee:

The State of Oregon on behalf of the University of Oregon - Eugene OR

International Classification:

C07D 213/42
C07D 213/56
C07D 401/04
C07D 333/20
C07F 9/82
C07F 7/24
C07F 3/08
C07F 3/06
C07F 3/14

US Classification:

546 3, 546338, 546337, 546257, 549 75, 546 2, 549 3

Abstract:

Disclosed herein is a class of tunable phenylacetylene compounds as well as compositions and methods for their use as host compounds for ligand binding. In certain examples the hosts report binding events by exhibiting altered spectroscopic properties, such as different fluorescent emission spectra.

US Patent:

20130096336, Apr 18, 2013

Filed:

Jun 15, 2011

Appl. No.:

13/704571

Inventors:

Michael M. Haley - Eugene OR, US
Daniel T. Chase - Eugene OR, US
Brad Rose - Eugene OR, US
Aaron G. Fix - Eugene OR, US

International Classification:

H01L 51/00

US Classification:

556429, 556431, 558411, 558427, 570128, 585 27, 585320

Abstract:

Indenofluorenes that include at least two alkynyl-containing substituents.

US Patent:

20140031559, Jan 30, 2014

Filed:

Dec 14, 2012

Appl. No.:

13/715979

Inventors:

Calden Carroll - Eugene OR, US
Michael M. Haley - Eugene OR, US
Jeff Engle - Eugene OR, US

Assignee:

State of Oregon, acting by and through the State Board of Higher Education on Behalf of University - Eugene OR

International Classification:

C07D 213/40
C07D 213/42

US Classification:

546332, 546338

Abstract:

A compound, or a salt thereof, having the formula

US Patent:

20190345113, Nov 14, 2019

Filed:

May 1, 2019

Appl. No.:

16/401037

Inventors:

- Eugene OR, US
- Missoula MT, US
Michael M. Haley - Eugene OR, US
Orion B. Berryman - Missoula MT, US
Asia M. Riel - Missoula MT, US
Daniel A. Decato - Missoula MT, US

Assignee:

University of Oregon - Eugene OR
University of Montana - Missoula MT

International Classification:

C07D 233/56
C07D 213/90
C07D 213/22
G01N 21/64

Abstract:

A compound, or a protonate or salt thereof, of formula I:

US Patent:

20170115262, Apr 27, 2017

Filed:

Dec 11, 2014

Appl. No.:

15/310601

Inventors:

- Eugene OR, US
Darren W. JOHNSON - Eugene OR, US
Michael M. HALEY - Eugene OR, US

International Classification:

G01N 31/22
C07C 275/34
C07D 251/24
C07C 275/42
C07C 335/16
C07C 275/30
C07C 335/18

Abstract:

A compound, or a protonate or salt thereof, having a formula I of: wherein Y represents an optionally substituted aromatic group; n is 1 or 2; a is 0 to 4; Rand Rare each independently H; optionally substituted alkyl; optionally substituted aralkyl; acyl; phosphonyl; —S0R; —C(0)R; —C(0)OR; —C(0)NRR; —C(0)CHR; or —C(S)—NRR; —S(0)R20; or —S0NRR, wherein R-Rare each independently H, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, or —C(0)R, wherein Ris H, optionally substituted alkyl, optionally substituted aralkyl, or optionally substituted aryl; and each Ris independently optionally substituted alkyl, halogen, optionally substituted alkoxy, optionally substituted carboxyl, amide; amino; or nitro.