Michael Eugene Hedrick

US Patent:

6994550, Feb 7, 2006

Filed:

Jul 17, 2003

Appl. No.:

10/622626

Inventors:

Kenneth E. Knapp - Livermore CA, US
Michael L. Hedrick - Livermore CA, US

Assignee:

Nano-Write Corporation - Livermore CA

International Classification:

A61C 13/08
A61C 5/08
A61C 5/10

US Classification:

433207, 433218, 433223, 427 226

Abstract:

A coating for a biomedical device is disclosed, including a metal layer and/or a ceramic layer, such as a layer of titanium (Ti) and a layer of titanium-nitride (TiN). The coating can form a coping for a crown for a tooth, the crown including a porcelain layer bonded to the titanium-nitride (TiN) layer. Methods for making and using a biomedical device are also disclosed, including vapor deposition of metal and/or ceramic layers, such as titanium (Ti) and titanium-nitride (TiN) layers. In one embodiment, the method includes forming a titanium (Ti) vapor that solidifies to form a titanium (Ti) layer; forming a titanium-nitride (TiN) vapor that coats the titanium (Ti) layer with a titanium-nitride (TiN) layer; and forming a porcelain layer on the titanium-nitride (TiN) layer. The porcelain can be sintered to form a dental crown or other device.

US Patent:

20060105297, May 18, 2006

Filed:

Dec 27, 2005

Appl. No.:

11/320116

Inventors:

Kenneth Knapp - Livermore CA, US
Michael Hedrick - Livermore CA, US
Brett Wells - Morgan Hill CA, US

International Classification:

A61C 13/08

US Classification:

433206000

Abstract:

Dental devices such as crowns, bridges and implants are disclosed, such devices comprising a self-supporting structural layer, a ceramic outer layer attached to the structural layer, and a porcelain layer attached to the ceramic layer, the ceramic outer layer made of a nitride, oxide or oxynitride of titanium (Ti) or zirconium (Zr). The devices are biocompatible and can have thin layers that are exactingly tailored. In one embodiment, a gold layer is disposed between the ceramic outer layer and the porcelain layer. In one embodiment, the gold layer comprises a nanocomposite of gold and oxides, nitrides or oxynitrides of indium, tin or zinc. In one embodiment, the structural layer is made of a cobalt alloy having a coefficient of expansion that substantially matches that of the porcelain layer. Methods for making and using such devices are also disclosed, including vapor deposition of metal and/or ceramic layers.

US Patent:

20190284293, Sep 19, 2019

Filed:

Mar 3, 2017

Appl. No.:

16/081115

Inventors:

- Princeton NJ, US
Alan J. KORMAN - Piedmont CA, US
Bryan C. BARNHART - San Francisco CA, US
Aaron P. YAMNIUK - Lawrenceville NJ, US
Mohan SRINIVASAN - Cupertino CA, US
Karla A. HENNING - Milpitas CA, US
Ming LEI - Princeton NJ, US
Emanuela SEGA - Cupertino CA, US
Angela GOODENOUGH - Morrisville PA, US
Guodong CHEN - East Brunswick NJ, US
John S. SACK - Lawrenceville NJ, US
Richard Y. HUANG - Bridgewater NJ, US
Martin J. CORBETT - Mount Holly NJ, US
Liang SCHWEIZER - Shanghai PR, CN
Sandra V. HATCHER - Hillsborough NJ, US
Rachel A. ALTURA - Belle Mead NJ, US
Haichun HUANG - Fremont CA, US
Pingping ZHANG - Cupertino CA, US
Edward J. HILT - Yardley PA, US
Michael Nathan HEDRICK - Doylestown PA, US

International Classification:

C07K 16/28
A61K 9/00

Abstract:

Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-CD73 antibody in combination with an immuno-oncology agent, such as an anti-PD-1 antibody.