- La Jolla CA, US Paul M. HERSHBERGER - La Jolla CA, US Satyamaheshwar PEDDIBHOTLA - La Jolla CA, US Patrick R. MALONEY - La Jolla CA, US Michael P. HEDRICK - La Jolla CA, US
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Inhibitors Of Low Molecular Weight Protein Tyrosine Phosphatase And Uses Thereof
- La Jolla CA, US Santhi R. GANJI - La Jolla CA, US Stephanie STANFORD - La Jolla CA, US Anthony PINKERTON - La Jolla CA, US Michael HEDRICK - La Jolla CA, US Robert ARDECKY - La Jolla CA, US
Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
- La Jolla CA, US Paul M. HERSHBERGER - La Jolla CA, US Satyamaheshwar PEDDIBHOTLA - La Jolla CA, US Patrick R. MALONEY - La Jolla CA, US Michael P. HEDRICK - La Jolla CA, US
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Compounds And Methods For Activating The Apoptotic Arm Of The Unfolded Protein Response
- Lawrence KS, US - Ann Arbor MI, US - Detroit MI, US - La Jolla CA, US Randal J. Kaufman - San Diego CA, US Thomas D.Y. Chung - Carlsbad CA, US Anthony B. Pinkerton - San Diego CA, US Michael Pablo Hedrick - Carlsbad CA, US
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Inhibitors Of Low Molecular Weight Protein Tyrosine Phosphatase And Uses Thereof
- La Jolla CA, US Santhi R. GANJI - La Jolla CA, US Stephanie STANFORD - La Jolla CA, US Anthony PINKERTON - La Jolla CA, US Thomas CHUNG - La Jolla CA, US Michael HEDRICK - La Jolla CA, US Robert ARDECKY - La Jolla CA, US
International Classification:
C07D 239/94 C07D 405/12 C07D 215/46 C07D 401/12
Abstract:
Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
- La Jolla CA, US Paul M. HERSHBERGER - La Jolla CA, US Satyamaheshwar PEDDIBHOTLA - La Jolla CA, US Patrick R. MALONEY - La Jolla CA, US Michael P. HEDRICK - La Jolla CA, US
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
- La Jolla CA, US - Durham NC, US Paul HERSHBERGER - La Jolla CA, US Satyamaheshwar PEDDIBHOTLA - La Jolla CA, US Michael HEDRICK - La Jolla CA, US Lawrence BARAK - La Jolla CA, US Marc CARON - La Jolla CA, US
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Compounds And Methods For Activating The Apoptotic Arm Of The Unfolded Protein Response
- Lawrence KS, US - Ann Arbor MI, US - Detroit MI, US - La Jolla CA, US Randal J. Kaufman - San Diego CA, US Thomas D.Y. Chung - Carlsbad CA, US Anthony B. Pinkerton - San Diego CA, US Michael Pablo Hedrick - Carlsbad CA, US
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Group Leader - Scientist, Conrad Prebys Center for Chemical Genomics at The Sanford-Burnham Medical Research Institute
Location:
Greater San Diego Area
Industry:
Biotechnology
Work:
The Sanford-Burnham Medical Research Institute since Apr 2007
Group Leader - Scientist, Conrad Prebys Center for Chemical Genomics
Neurocrine Biosciences 2003 - 2007
Associate Scientist
Ontogen Corporation 2001 - 2003
Senior Research Associate
The Scripps Research Institute 1998 - 2001
Research Technician III
The Cancer Research Institute at Arizona State University 1996 - 1998
Research Diver/Technician
Education:
Arizona State University 1994 - 1995
BS, Biology
Hawaii Pacific University 1991 - 1994
BA, Marine Science
Nowhere
Unemployed
Payless ShoeSource May 2011 - Oct 2011
Store Manager
Palomar College Bookstore Nov 1988 - Apr 2011
Bookstore Assistant Manager
Southland Fabrication Jan 1995 - Jan 1998
Sales Representative
Enterprise Rent a Car Jan 1993 - Jan 1995
Assistant Manager
Showtime Networks 2011 - 2013
Manager, Production
20th Century Fox 2010 - 2011
Manager, Global Content Development
Showtime Networks 2010 - 2010
Director, International DVD production, Broadcast Operations
New Line Cinema 1996 - 2008
Director, Int'l Distribution
E! Entertainment Television 1997 - 1998
Assistant to Director and Manager - Building Management
Trex Company - Winchester, VA since Nov 2012
Application Developer / Analyst
Transprint - Harrisonburg, VA Apr 2012 - Oct 2012
Computer Operations Manager
Transprint May 2007 - Apr 2012
Manager Of Process Engineering
Transprint May 2003 - May 2007
Computer Programmer/IT Specialist
Pilgrim's Pride Feb 1994 - May 2003
QA Laboratory Technician
2007 to 2000 Scientist, Group LeaderNeurocrine Biosciences San Diego, CA 2003 to 2007 Associate ScientistOntogen Corporation Carlsbad, CA 2001 to 2003 Senior Research AssociateThe Scripps Research Institute La Jolla, CA 1998 to 2001 Research Technician IIIThe Cancer Research Institute Tempe, AZ 1996 to 1998 Research Technician
Education:
Arizona State University Tempe, AZ 1997 B. S. in BiologyHawaii Pacific University Honolulu, HI 1994 B. A. in Marine Science
michael hedrick (1984-1988), Leah Rudd (1975-1979), Ryan Krutz (1999-2003), Brad Booker (1966-1970), Rick McWhinnie (1963-1967), Sarah Faith Bourdeaux (1969-1973)