Michael J Heffernan

US Patent:

8252846, Aug 28, 2012

Filed:

Mar 12, 2008

Appl. No.:

12/075667

Inventors:

Niren Murthy - Atlanta GA, US
Bali Pulendran - Alpharetta GA, US
Robert H. Pierce - Palo Alto CA, US
Michael John Heffernan - Atlanta GA, US
Jihua Hao - Cleveland OH, US
Michael Davis - Atlanta GA, US
Stephen C. Yang - Mableton GA, US

Assignee:

Emory University - Atlanta GA
Georgia Tech Research Corporation - Atlanta GA
University of Rochester - Rochester NY

International Classification:

A61K 47/30
A61K 38/18
A61K 31/70
A61K 47/48
A01N 43/04
C08G 2/00

US Classification:

5147723, 514 76, 514 23, 525 541, 525 542, 528220

Abstract:

The present invention provides biodegradable particles (e. g. , three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.

US Patent:

20100062968, Mar 11, 2010

Filed:

May 10, 2006

Appl. No.:

11/920330

Inventors:

Bali Pulendran - Alpharetta GA, US
Niren Murthy - Atlanta GA, US
Robert H. Pierce - Rochester NY, US
Michael John Heffernan - Atlanta GA, US
Jihua Hao - Cleveland OH, US

International Classification:

A61K 47/00
C08G 65/34
A61K 31/7088
A61P 37/00
A61P 35/00
A61P 31/12
A61P 3/10
C07K 1/00
A61K 38/00

US Classification:

514 2, 528425, 5147723, 530345, 514 44 A, 424 7827, 525 542

Abstract:

The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.

US Patent:

20220192810, Jun 23, 2022

Filed:

Dec 21, 2021

Appl. No.:

17/557970

Inventors:

- Houston TX, US
Michael John Heffernan - Katy TX, US
Deepti Gopinath - Houston TX, US
Christine Luk - Houston TX, US
Carine Rizk - Houston TX, US
Amanda Gibbens - Houston TX, US

International Classification:

A61F 2/00

Abstract:

The present invention relates to the application of medical devices that manage urinary incontinence. The inter-bladder/urethra implanted device allows for passive urine leakage above a threshold bladder pressure and subject-controlled opening and closing of a valve to allow urine passage, below the threshold bladder pressure. The valve is preferably a deformable sac which seals against the interior of the urethra when closed. The valve can be opened by withdrawing slightly from the urethra surface. Passive urine leakage to prevent over-pressure can be facilitated by including external channels on the valve sac. In another embodiment, the valve sac has a central passage which expands and contracts for opening and closing, respectively.

US Patent:

20200393453, Dec 17, 2020

Filed:

Aug 5, 2020

Appl. No.:

16/985475

Inventors:

- Houston TX, US
Leo Linbeck, III - Houton TX, US
Michael John Heffernan - Katy TX, US

International Classification:

G01N 33/543
G01N 33/53
G01N 21/78
B01L 3/00

Abstract:

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change

US Patent:

20190091691, Mar 28, 2019

Filed:

Nov 12, 2018

Appl. No.:

16/186922

Inventors:

- HOUSTON TX, US
Leo Linbeck, III - Houston TX, US
Michael John Heffernan - Katy TX, US

International Classification:

B01L 3/00
G01N 33/483
C12M 1/32

Abstract:

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change

US Patent:

20190091692, Mar 28, 2019

Filed:

Nov 13, 2018

Appl. No.:

16/188329

Inventors:

- Houston TX, US
Leo LlNBECK, III - Houston TX, US
Michael John Heffernan - Katy TX, US
Brad Ernest Munoz - Spring TX, US

International Classification:

B01L 3/00
G01N 33/483
C12M 1/32

Abstract:

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change

US Patent:

20180111123, Apr 26, 2018

Filed:

Oct 25, 2017

Appl. No.:

15/793384

Inventors:

- Houston TX, US
Leo LlNBECK, III - Houston TX, US
Michael John Heffernan - Katy TX, US
Atul Varadhachary - Bellaire TX, US

International Classification:

B01L 3/00

Abstract:

The invention relates to conducting assays with an apparatus including a substantially transparent assay cartridge loaded with magnetic beads, and a magnet carrier base positioned below a scanning platform holding the assay cartridge. A microcomputer controls a stepping motor which controls movement of the magnet carrier base, and causes the magnetic beads to travel from one well to another, where the wells contain different assay reagents. An electromagnetic coil-spring assembly induces mixing of well contents with the magnetic beads on actuation. The assay cartridge is authenticated by sending its encoded identifier to a server or website, and assay instructions are provided remotely to the microcomputer. Following assay completion, the cartridge can have color change or other assay indication detected, and the results sent to the server or website or another recipient. Concurrently assaying a control allows modification of assay results based on measured field conditions.

US Patent:

20180111128, Apr 26, 2018

Filed:

Oct 25, 2017

Appl. No.:

15/793490

Inventors:

- Houston TX, US
Leo LlNBECK, III - Houston TX, US
Michael John Heffernan - Katy TX, US
Brad Ernest Munoz - Spring TX, US
Atul Varadhachary - Bellaire TX, US

International Classification:

B01L 3/00
C12M 1/32
G01N 33/483

Abstract:

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change