Michael J Hendrick

US Patent:

53566440, Oct 18, 1994

Filed:

Oct 6, 1992

Appl. No.:

7/957648

Inventors:

Michael E. Hendrick - Groton CT
Robert A. Reimer - Mystic CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

A23L 1307

US Classification:

426 99

Abstract:

There is disclosed a low calorie fat substitute comprising an outer coating of a digestible fat surrounding an inner core of a low caloric or non-caloric material.

US Patent:

48701904, Sep 26, 1989

Filed:

Oct 12, 1988

Appl. No.:

7/256588

Inventors:

Thomas M. Brennan - Groton CT
Michael E. Hendrick - Groton CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D33902

US Classification:

549 38

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is methyl, hydroxymethyl, ethyl, n-propyl or isopropyl; R is ##STR2## where at least one of R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, and the sum of the carbon atoms in R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 6 is not greater than six; and when both of R. sup. 3 and R. sup. 4 or R. sup. 5 and R. sup. 6 are alkyl, they are methyl or ethyl. Said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amine and amide intermediates useful in their production.

US Patent:

45173796, May 14, 1985

Filed:

Apr 1, 1983

Appl. No.:

6/481456

Inventors:

Thomas M. Brennan - Old Lyme CT
Michael E. Hendrick - Groton CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07C10337
C07C10352

US Classification:

564193

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is CH. sub. 2 OH or CH. sub. 2 OCH. sub. 3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## where at least one of R. sup. 3, F. sup. 4, R. sup. 5, R. sup. 6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO. sub. 2, C. dbd. O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 6 is not greater than six, and when both of R. sup. 3 and R. sup. 4 or R. sup. 5 and R. sup. 6 are alkyl they are methyl or ethyl, ##STR3## where one of R. sup. 7, R. sup. 8, R. sup.

US Patent:

56816014, Oct 28, 1997

Filed:

Apr 25, 1996

Appl. No.:

8/637463

Inventors:

Michael E. Hendrick - Groton CT
Robert A. Reimer - Mystic CT

Assignee:

Cultor Ltd. - Helsinki

International Classification:

A23L 1307

US Classification:

426 99

Abstract:

There is disclosed a low calorie fat substitute comprising an outer coating of a digestible fat surrounding an inner core of a low caloric or non-caloric material.

US Patent:

48554545, Aug 8, 1989

Filed:

Jul 13, 1988

Appl. No.:

7/218245

Inventors:

Thomas M. Brennan - Old Lyme CT
Michael E. Hendrick - Groton CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D33336
C07D33348

US Classification:

549 68

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## where at least one of R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO. sub. 2, C. dbd. O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 6 is not greater than six, and when both of R. sup. 3 and R. sup. 4 or R. sup. 5 and R. sup. 6 are alkyl they are methyl or ethyl, ##STR3## where one of R. sup. 7, R. sup. 8, R. sup.

US Patent:

48944645, Jan 16, 1990

Filed:

Oct 26, 1988

Appl. No.:

7/262627

Inventors:

Thomas M. Brennan - Groton CT
Michael E. Hendrick - Groton CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D33104
C07D33336
C07D33502

US Classification:

549 88

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## where at least one of R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO. sub. 2 C. dbd. O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 6 is not greater than six, and when both of R. sup. 3 and R. sup. 4 or R. sup. 5 and R. sup. 6 are alkyl they are methyl or ethyl, ##STR3## where one of R. sup. 7, R. sup. 8, R. sup.

US Patent:

44119259, Oct 25, 1983

Filed:

Nov 5, 1980

Appl. No.:

6/201745

Inventors:

Thomas M. Brennan - Old Lyme CT
Michael E. Hendrick - Groton CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

A23L 1236

US Classification:

426548

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amine and amide intermediates useful in their production.

US Patent:

43991637, Aug 16, 1983

Filed:

Jun 26, 1981

Appl. No.:

6/276243

Inventors:

Thomas M. Brennan - Old Lyme CT
Michael E. Hendrick - Groton CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

A23L 1236

US Classification:

426548

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is CH. sub. 2 OH or CH. sub. 2 OCH. sub. 3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butyl-carbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amide intermediates useful in their production.