Michael Joseph Hendrick

US Patent:

47972980, Jan 10, 1989

Filed:

Dec 18, 1986

Appl. No.:

6/944269

Inventors:

Thomas M. Brennan - Mountain View CA
Michael E. Hendrick - Groton CT

Assignee:

Pfizer, Inc. - New York NY

International Classification:

C07D33902
A23L 1236

US Classification:

426548

Abstract:

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R. sup. a is methyl, hydroxymethyl, ethyl, n-propyl or isopropyl; R is ##STR2## where at least one of R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, and the sum of the carbon atoms in R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 6 is not greater than six; and when both of R. sup. 3 and R. sup. 4 or R. sup. 5 and R. sup. 6 are alkyl, they are methyl or ethyl. Said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amine and amide intermediates useful in their production.