Michael C Hiles

US Patent:

6358284, Mar 19, 2002

Filed:

Jun 2, 1999

Appl. No.:

09/324989

Inventors:

Neal E. Fearnot - West Lafayette IN
Michael C. Hiles - Lafayette IN

Assignee:

Med Institute, Inc. - West Lafayette IN
Cook Biotech, Inc. - West Lafayette IN

International Classification:

A61F 236

US Classification:

623 2372, 623 144, 424551

Abstract:

An easy-to-produce and mechanically strong tube of an implantable graft prosthesis has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the graft prosthesis generally involves wrapping multiple sheets of a purified, collagen-based matrix structure around a mandrel, compressing and drying the tissue on the mandrel before removing the construct for eventual use.

US Patent:

6475232, Nov 5, 2002

Filed:

Jun 10, 1999

Appl. No.:

09/319718

Inventors:

Charles F. Babbs - West Lafayette IN
Neal F. Fearnot - West Lafayette IN
Stephen F. Badylak - West Lafayette IN
Leslie A Geddes - West Lafayette IN
Michael C. Hiles - Lafayette IN
Joe D. Bourland - West Lafayette IN

Assignee:

Purdue Research Foundation - West Lafayette IN

International Classification:

A61F 206

US Classification:

623 113

Abstract:

A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent ( ) covered with submucosal tissue ( ) wherein the stent ( ) is formed for receiving the distal end of a catheter ( ) having an inflatable balloon ( ).

US Patent:

6666892, Dec 23, 2003

Filed:

May 27, 1999

Appl. No.:

09/320933

Inventors:

Michael C. Hiles - Lafayette IN
Umesh H. Patel - West Lafayette IN

Assignee:

Cook Biotech Incorporated - West Lafayette IN

International Classification:

A61F 202

US Classification:

623 2372, 623925, 523113

Abstract:

The invention involves a submucosa tissue that has the capability of being shape formed or shape configured. The submucosa involves a purified form of submucosa tissue. Optionally, the submucosa can be packaged in such a manner to permit sterility or maintain sterility of the submucosa.

US Patent:

7087089, Aug 8, 2006

Filed:

Jun 28, 2002

Appl. No.:

10/186150

Inventors:

Umesh H. Patel - West Lafayette IN, US
Michael C. Hiles - Lafayette IN, US
Jason P. Hodde - West Lafayette IN, US

Assignee:

Cook Biotech Incorporated - West Lafayette IN

International Classification:

A61F 2/02

US Classification:

623 2372, 623 147, 523105, 424572

Abstract:

The invention provides tissue graft compositions comprising collagen-based extracellular matrices derived from renal capsules of warm-blooded vertebrates. The invention further provides a process of harvesting and purifying a renal capsule to provide an extracellular matrix material having beneficial use as a tissue graft and/or cell growth material.

US Patent:

7387604, Jun 17, 2008

Filed:

Nov 3, 2005

Appl. No.:

11/266166

Inventors:

Brian C. Case - Bloomington IN, US
Jacob A Flagle - Indianapolis IN, US
Michael C. Hiles - Lafayette IN, US
F. Joseph Obermiller - West Lafayette IN, US
Umesh H. Patel - West Lafayette IN, US

Assignee:

Cook Incorporated - Bloomington IN

International Classification:

A61F 2/00
A61F 13/00

US Classification:

600 37, 623 124

Abstract:

This invention relates in one aspect to the treatment of a valve-associated region of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

US Patent:

7485138, Feb 3, 2009

Filed:

Feb 6, 2002

Appl. No.:

10/068212

Inventors:

Neal E. Fearnot - West Lafayette IN, US
Michael C. Hiles - Lafayette IN, US

Assignee:

Cook Biotech Incorporated - West Lafayette IN

International Classification:

A61F 2/06

US Classification:

623 11, 623917, 623921, 623 144

Abstract:

Described are medical devices which are or can be used to form tubular medical devices, and related methods. Preferred devices include tubular grafts of biomaterial having lumen walls which present no seam edge that traverses the entire length of the lumen, illustratively including devices having lumen walls which have a discontinuous seam presenting multiple seam edges. Such a device may include a tubular structure formed by inserting a plurality of extensions of a biomaterial sheet through a plurality of corresponding apertures of the sheet.

US Patent:

7652077, Jan 26, 2010

Filed:

Mar 26, 2004

Appl. No.:

10/811343

Inventors:

William A. Cook - Bloomington IN, US
Michael C. Hiles - Lafayette IN, US
Thomas G. Kozma - McHenry IL, US
Umesh H. Patel - West Lafayette IN, US

Assignee:

Cook Incorporated - Bloomington IN
Cook Biotech, Inc. - West Lafayette IN
MED Institute Incorporated - West Lafayette IN

International Classification:

A61F 2/00

US Classification:

523113, 424426, 623 2375, 8 9411

Abstract:

A graft prostheses (), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

US Patent:

7699895, Apr 20, 2010

Filed:

Dec 23, 2003

Appl. No.:

10/744420

Inventors:

Michael C. Hiles - Lafayette IN, US
Umesh H. Patel - West Lafayette IN, US

Assignee:

Cook Biotech Incorporated - West Lafayette IN

International Classification:

A61F 2/02

US Classification:

623 2372, 424426

Abstract:

The invention involves a submucosa tissue that has the capability of being shape formed or shape configured. The submucosa involves a purified form of submucosa tissue. Optionally, the submucosa can be packaged in such a manner to permit sterility or maintain sterility of the submucosa.