Michael K Hoffman

US Patent:

20130304604, Nov 14, 2013

Filed:

Nov 2, 2012

Appl. No.:

13/668168

Inventors:

Michael Theodor Hoffman - Menlo Park CA, US
Chad James Phillips - Portland OR, US

International Classification:

G06Q 30/06

US Classification:

705 265

Abstract:

A system and method are provided for creating, managing, rendering and delivering digitally synthesized products that can be automatically generated as a function of variable attributes provided by a variety of sources. The system can include design tools for creating workflows that describe the rules for dynamically creating digital products; licensing system to manage product licensing; distributed synthesis systems for generating products; location based services to manage location/time specific products; sharing services for transferring products; web services for composing and sharing products; mobile applications for composing and sharing products; notification services for notifying participants of system state changes; databases for managing the components of the system; extension services for externally developed system extensions; API services for external management and utilization of the system; and e-commerce services for paying or collecting fees for usage of the system by contributors or users.

US Patent:

56820380, Oct 28, 1997

Filed:

Apr 6, 1995

Appl. No.:

8/417744

Inventors:

Michael A. Hoffman - Carmel CA

Assignee:

Becton Dickinson and Company - Franklin Lakes

International Classification:

G01J 158
G01J 351
G01N 2164
G01N 3348

US Classification:

2504581

Abstract:

A flow cytometry system includes a flow tube through which particles marked with different fluorochromes pass from a first location, illuminated by a red laser, to a second location, illuminated by a blue laser. A "red" photodetector is optically coupled to detect red fluorescence from both locations. "Yellow" and "green" photodetectors respectively detect yellow and green fluorescence from the second location, while a "scattered light" detector detects scattered light from the second location. During a sample run, the red photodetector can output pulses that correspond primarily to APC fluorochrome at the first location and to PerCP at the second location respectively. A delay device delays the APC pulse relative to the PerCP pulse so that the peaks can be scaled and subtracted in the analog electrical domain to remove APC/PerCP crosstalk. The delay is calibrated using a set of APC tagged cells. Each of these cells generates a red fluorescence electrical pulse while at the first location and a scattered light pulse while at the second location.

US Patent:

45387338, Sep 3, 1985

Filed:

Oct 14, 1983

Appl. No.:

6/542285

Inventors:

Michael A. Hoffman - Sunnyvale CA

Assignee:

Becton, Dickinson and Company - Paramus NJ

International Classification:

B07C 5342

US Classification:

209 31

Abstract:

An apparatus for sorting particles comprises a nozzle or the like for forming discrete droplets of particles from a flowing liquid stream containing those particles. A detector is provided for detecting particles in the stream. A charging electrode, responsive to the detector, charges some droplets of selective interest with a positive electrical charge and some with a negative electrical charge. Electrical deflecting plates deflect charged droplets of selective interest. Droplets of selective interest, charged with opposite polarities, are collected in a collection well inside which the electrical charge is substantially neutralized. A method for sorting particles, such as cells or the like, substantially in accordance with the above-described apparatus is another aspect of the present invention.

US Patent:

60988029, Aug 8, 2000

Filed:

Dec 17, 1998

Appl. No.:

9/213694

Inventors:

David Asa - Carmel CA
Michael Hoffman - Carmel CA

International Classification:

B65D 8520

US Classification:

206443

Abstract:

A deep well rack assembly for pipette tips and the like includes an enclosure having a plurality of openings in a top wall thereof, a plurality of wells in the enclosure extending below the top wall and openings for receiving and retaining pipette tips, and a cover for overlying the top wall of the enclosure and the wells and pipette tips. The top wall of the enclosure either has a plurality of annular depressions formed therein and surrounding the openings or a plurality of raised annular rings formed thereon and surrounding the openings. The wells are disposed within an interior cavity of the enclosure. Each well has a continuous side wall attached at an open top end to the top wall and surrounding one of the openings therein. Each well is adapated to receive a pipette tip such that the pipette tip is disposable within the well and the respective annular depression or raised annular ring of the top wall of the enclosure. The cover can be in the form of a slidable lid or one or more layers of film applied over the top wall of the enclosure and covering the openings and wells and pipette tips therein as well as the annular depressions or raised annular rings of the top wall of the enclosure.