A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.
Charles A. Stevens - Lansdale PA Michael R. Hoy - North Wales PA Edward J. Roche - Paoli PA
Assignee:
McNeil-PPC, Inc. - Skillman NJ
International Classification:
B05D 312 A61K 924 A61J 300
US Classification:
427 214
Abstract:
A method of making solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier. The barrier is formed by coating with a polymer impermeable to simethicone.
The present invention relates to a dosage form containing a common enclosure of polymeric material. The enclosure contains multiple phases of semi-solid fill materials containing active ingredients.
Taste Mask Coatings For Preparation Of Chewable Pharmaceutical Tablets
Michael R. Hoy - Sellersville PA Edward J. Roche - Paoli PA
Assignee:
McNeil-PPC, Inc. - Milltown NJ
International Classification:
A61K 920
US Classification:
424441
Abstract:
Chewable tablets are made from a coated medicament wherein the coating comprises a mixture of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and a cellulose ester, e. g. cellulose acetate, cellulose acetate butyrate, cellulose triacetate or a combination thereof and optionally polyvinyl pyrrolidone, and a process for making such tablets and a method of providing taste masking and sustained releasing of medicaments utilizing such coatings.
Charles A. Stevens - Lansdale PA Michael R. Hoy - North Wales PA Edward J. Roche - Paoli PA
Assignee:
McNeil-PPC, Inc. - Skillman NJ
International Classification:
A61K 924 A61K 926 A61K 952
US Classification:
424472
Abstract:
A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.
Brid T. Devlin - Conshohocken PA Michael R. Hoy - Sellersville PA
Assignee:
McNeil-PPC, Inc. - Skillman NJ
International Classification:
A61K 948
US Classification:
424452
Abstract:
The present invention relates to a semi-solid fill material for a soft gelatin capsule containing a therapeutically effective amount of an antiflatulent. The semi-solid is sufficiently viscous so that it cannot be expelled readily at room temperature from the capsule with a syringe.
President & CEO at Valdé Therapeutics, LLC, Partner at Concerted Clinical Monitoring, LLC, Owner at Philadelphia Clinical Pharmacology Associates, LLC
Location:
Greater Philadelphia Area
Industry:
Biotechnology
Work:
Valdé Therapeutics, LLC since Sep 2009
President & CEO
Concerted Clinical Monitoring, LLC since May 2009
Partner
Philadelphia Clinical Pharmacology Associates, LLC since Sep 2007
Owner
Drexel University College of Medicine Dec 2004 - Dec 2008
Adjunct Professor
Centocor Jul 2006 - Sep 2007
Senior Research Scientist
Education:
Thomas Jefferson University 2001 - 2005
MS, Pharmacology
Albright College 1992 - 1996
BS, Biochemistry
Albright College 1986 - 1990
BS, Business Administration
Pricing Manager at The Pep Boys - Manny, Moe and Jack, Pricing Manager at Pep Boys, Manager - Pricing at Pep Boys Auto, Planogram Manager at The Pep Boys
Location:
Greater Philadelphia Area
Industry:
Automotive
Work:
The Pep Boys - Manny, Moe and Jack since Mar 1998
Pricing Manager
Pep Boys since 1998
Pricing Manager
Pep Boys Auto since 1998
Manager - Pricing
The Pep Boys since Mar 1998
Planogram Manager
Best Products Jul 1994 - Nov 1996
Manager
Education:
Kutztown University of Pennsylvania 1986 - 1989
BS, Business - Management
Central Bucks East HS