Michael E Hudson

US Patent:

20130296192, Nov 7, 2013

Filed:

Nov 10, 2011

Appl. No.:

13/884446

Inventors:

Joseph Jacobson - Newton MA, US
Michael E. Hudson - Framingham MA, US
Larry Li-Yang Chu - Brighton MA, US

Assignee:

Gen9, Inc. - Cambridge MA

International Classification:

C12N 15/10

US Classification:

506 11, 506 26, 506 18

Abstract:

Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.

US Patent:

20220370599, Nov 24, 2022

Filed:

May 2, 2022

Appl. No.:

17/734703

Inventors:

- Medford MA, US
Christopher J.H. DAVITT - Jamaica Plain MA, US
Ian HILL - Malden MA, US
Lorenzo AULISA - Chesterfield MO, US
Marcelo SAMSA - Hanover MD, US
Nabanita DE - Lexington MA, US
Michael HUDSON - Medford MA, US
Rachit JAIN - Medford MA, US
Himanshu DHAMANKAR - Arlington MA, US
William FARMER - Concord MA, US
Christopher GREGG - Melrose MA, US

International Classification:

A61K 39/215
C07K 14/005

Abstract:

In the various aspects and embodiments, this disclosure provides messenger RNA (mRNA) constructs for therapeutic delivery, as well as methods for making such mRNA constructs and pharmaceutical compositions comprising the same (including mRNA vaccine compositions). In still other aspects, the invention provides methods for treating patients by expression of therapeutic proteins, including for preventing or reducing probability of infection by, or illness involving, a virus. Exemplary viruses include coronaviruses (such as SARS-CoV-2 and variants therefore) and influenza viruses, among others.

US Patent:

20220333096, Oct 20, 2022

Filed:

Nov 22, 2021

Appl. No.:

17/532065

Inventors:

- Boston MA, US
Michael E. Hudson - Framingham MA, US
Li-Yun A. Kung - Arlington MA, US

Assignee:

Gen9, Inc. - Boston MA

International Classification:

C12N 15/10
C12Q 1/6874

Abstract:

Methods and compositions relate to the production of high fidelity nucleic acids using high throughput sequencing.

US Patent:

20210380968, Dec 9, 2021

Filed:

Aug 25, 2021

Appl. No.:

17/412100

Inventors:

- Boston MA, US
Daniel Schindler - Newton Upper Falls MA, US
Ishtiaq Saaem - Chelsea MA, US
Scott S. Lawton - Bedford MA, US
Martin J. Goldberg - Saratoga CA, US
Michael E. Hudson - Framingham MA, US
Li-Yun A. Kung - Arlington MA, US

Assignee:

Gen9, Inc. - Boston MA

International Classification:

C12N 15/10
C12P 19/34

Abstract:

Aspects of the invention relate to methods, compositions for designing and producing a target nucleic acid. In particular, aspects of the invention relate to the multiplex synthesis of target polynucleotides.

US Patent:

20210339219, Nov 4, 2021

Filed:

Jul 16, 2021

Appl. No.:

17/378133

Inventors:

- Boston MA, US
Li-Yun A. Kung - Arlington MA, US
Andrew Kirk Wilson - Arlington MA, US
Senthil Ramu - Boston MA, US
Daniel Schindler - Newton Upper Falls MA, US
Michael E. Hudson - Framingham MA, US

Assignee:

Gen9, Inc. - Boston MA

International Classification:

B01J 19/00
C12N 15/10
C12N 15/66

Abstract:

Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

US Patent:

20210207132, Jul 8, 2021

Filed:

Mar 15, 2021

Appl. No.:

17/202311

Inventors:

- Boston MA, US
Michael E. Hudson - Framingham MA, US
Larry Li-Yang Chu - Cambridge MA, US

Assignee:

Gen9, Inc. - Boston MA

International Classification:

C12N 15/10
B01J 19/00
C40B 50/14

Abstract:

Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.

US Patent:

20200197896, Jun 25, 2020

Filed:

Aug 7, 2019

Appl. No.:

16/533892

Inventors:

- Boston MA, US
Li-yun A. Kung - Arlington MA, US
Andrew Kirk Wilson - Arlington MA, US
Senthil Ramu - Boston MA, US
Daniel Schindler - Newton MA, US
Michael Hudson - Framingham MA, US

Assignee:

Gen9, Inc. - Boston MA

International Classification:

B01J 19/00
C12N 15/10
C12N 15/66

Abstract:

Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

US Patent:

20200181591, Jun 11, 2020

Filed:

Dec 13, 2019

Appl. No.:

16/713529

Inventors:

- Boston MA, US
Ishtiaq Saaem - Chelsea MA, US
Michael E. Hudson - Framingham MA, US
Devin Leake - Lexington MA, US

Assignee:

Gen9, Inc. - Boston MA

International Classification:

C12N 9/22
C12N 15/62
C12N 15/66
C12N 15/10
C12P 19/34

Abstract:

Aspects of the disclosure related to compositions and methods for site-directed DNA nicking and/or cleaving, and use thereof in, for example, polynucleotide assembly.