The invention provides α-mimetic structures represented by Formula (VI) and a chemical library relating thereto. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat cancer stem cells.
Alpha-Helix Mimetics And Methods Relating To The Treatment Of Fibrosis
Michael Kahn - Altadena CA, US Masakatsu Eguchi - Bellevue WA, US
Assignee:
Institute for Chemical Genomics - Altadena CA
International Classification:
A61K 31/553 A61K 31/554 A61K 31/519
US Classification:
51421109, 5142621
Abstract:
The invention provides α-helix mimetic structures and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of diseases including fibrosis, such as pulmonary fibrosis.
Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.
Defined Conditions For Human Embryonic Stem Cell Culture And Passage
Michael Kahn - Altadena CA, US Kouichi Hasegawa - Pasadena CA, US Jia-Ling Teo - Altadena CA, US Michael McMillan - Alhambra CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
C12N 5/0735
US Classification:
435366, 435404
Abstract:
The invention relates to human pluripotent cells. More specifically, the invention provides a chemically defined xeno-free culture system that allows for long term expansion of human pluripotent cells. This culture system allows for human pluripotent cell lines to be maintained in the pluripotent state for an extended time while maintaining a normal karyotype and the ability to differentiate into all three germ layers.
Michael N. Kahn - Woodbury NY George Spector - New York NY
International Classification:
A45D 4026
US Classification:
132320
Abstract:
A lotion wand is provided for dispensing suntan lotion from a suntan lotion squeeze bottle having a neck. The wand consists of a cap sized to fit over and engage with the neck of the suntan lotion squeeze bottle. A hollow tube extends upwardly form the cap. A holder is slightly angularly positioned on an upper end of the hollow tube. A sponge having a central aperture is carried in the holder. When the squeeze bottle is compressed the suntan lotion will travel through the hollow tube into the sponge from the central aperture to allow a user to reach their entire body to apply the suntan lotion thereto.
Described herein are devices and systems relating to sports training equipment, for example, for baseball. These devices and systems can comprise a mat with markers identifying a plurality of positions on the mat. In some embodiments, the system can comprise removably attachable footpads to identify ideal foot positions for an athletic performance. In some embodiments, the footpads comprise one or more pressure sensors. The system can comprise one or more position sensors on a ball, and one or more position sensors removably attachable to a hand-held sports instrument. In some embodiments, the system can comprise a memory, communicatively coupled to a processor and a camera, with executable instructions to implement a set-up component, a user recognition component, a practice component, and instructional component, and a play component.
Targeting Wnt Signaling For Improved Glioma Immunotherapy
This disclosure relates to cells that express a chimeric antigen receptor that targets IL13Rα2 and/or HER2 and methods for treating a brain tumor by administering a population of cells expressing a chimeric antigen receptor that targets IL13Rα2 and/or HER2 in combination with a Wnt/β-catenin pathway modulator to a subject having a brain tumor.
Jun 2011 to 2000 Loan Administrator, Commercial Real EstateIndependent ConsultantForest Hills, NY Nov 2008 to Feb 2011Sullivan & Worcester LLP New York, NY Feb 2007 to Oct 2008 AssociateLawrence and Walsh, P.C Hempstead, NY Oct 2005 to Feb 2007 Associate
Education:
NYU Schack Institute of Real Estate New York, NY 2013 Certificate in Finance and InvestmentFordham University School of Law New York, NY 2005 J.D.Cornell University, College of Human Ecology Ithaca, NY 2001 B.S.
Ropes & Gray LLP 45 Rockefeller Plaza, New York, NY 10111 (212)5969186 (Office), (646)7282872 (Fax)
Licenses:
New York - Currently registered 2002
Education:
Fordham University School of Law Degree - JD - Juris Doctor - Law Graduated - 2001 University of Pennsylvania Degree - BA - Bachelor of Arts - Philosophy Graduated - 1998 University of Pennsylvania Degree - BA - Bachelor of Arts - Economics Graduated - 1998 University of Pennsylvania Degree - BA - Bachelor of Arts - Science Graduated - 1998
stop dividing and eventually die off. During this twilight period, such cells can do significant harm. By analogy to one moldy piece of fruit that corrupts the entire bowl, a small number of senescent cells can cause inflammation that damages neighboring cells, explains Michael Kahn, Ph.D., a chem
Date: Nov 05, 2023
Category: Health
Source: Google
The Fabelmans review: One of Steven Spielberg’s best movies tells his own story
g for a way past Burts idiosyncrasies. But the once-tight bond shared by mother and son untethers when Sammy learns a disturbing secret about Mitzi (in a sequence elegantly assembled by Fabelmans editors Sarah Broshar and Michael Kahn) that causes him to temporarily lose his love of movie-making.
onald De Line, Dan Farah, Kristie Macosko Krieger, Steven SpielbergExecutive producers: Bruce Berman, Christopher DeFaria, Daniel Lupi, Adam SomnerDirector of photography: Janusz KaminskiProduction designer: Adam StockhausenCostume designer: Kasia Walicka-MaimoneEditors: Sarah Broshar, Michael Kahn
Date: Mar 12, 2018
Category: Entertainment
Source: Google
Steven Spielberg's 'The Post' is a movie about the past that speaks to our times
Collaborating with his regular team, including cinematographer Janusz Kaminski, editor Michael Kahn (Sarah Broshar co-edited), production designer Rick Carter and composer John Williams (costume designer Ann Roth is new to the group), Spielberg seems to have been energized by the self-imposed time r
Date: Dec 21, 2017
Category: Entertainment
Source: Google
Knives are out for theaters that bear the name 'Shakespeare'
First of all, they clearly are not people who have seen the show or been to our theater, said Michael Kahn, artistic director of Shakespeare Theatre Company. Im assuming that some letters gone out to a lot of people, and people got confused and decided to write to different Shakespeare theaters
Date: Jun 16, 2017
Source: Google
'The BFG' shows that, despite some stumbles, Spielberg endures
Thankfully, where the writing may falter, Spielbergs regular below-the-line trio of composer John Williams, editor Michael Kahn and cinematographer Janusz Kamiski realize Spielbergs cinematic vision. Williamss music swells at just the right moments, sucking the audience into his regular partner
Date: Jul 06, 2016
Category: Entertainment
Source: Google
The Screenwriter of “ET” and “The BFG” Says Goodbye
at that pointthe government abducts the alien, who is then rescued and released by the boybut, while Spielberg was editing Raiders with Michael Kahn, he invited Mathison into their editing suite, and, when his attention was free, the two of them hashed out the rest of the film on small cards, sc
pielberg, Frank Marshall, Sam MercerExecutive producers: Kathleen Kennedy, John Madden, Kristie Macosko Krieger, Michael SiegelDirector of photography: Janusz KaminskyProduction designers: Rick Carter, Robert StrombergCostume designer: Joanna JohnstonEditor: Michael Kahn
Date: May 16, 2016
Category: Entertainment
Source: Google
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Michael Kahn
Lived:
New York, NY
Work:
MKahnCreative - Freelance
Education:
City College; Harvard
Michael Kahn
Lived:
PINK HOUSE' BULD. #18 Brooklyn ny Jamesburg nj Old bridge nj
Work:
TSS
Education:
FKLane
Youtube
DP/30 Industry Legends: editor Michael Kahn
Michael Kahn celebrates his 75th birthday with three new films coming ...
Duration:
40m 1s
Editor Michael Kahn, ACE Discusses the Most D...
Manhattan Edit Workshop presents: Sight, Sound & Story - Michael Kahn,...
Duration:
3m 7s
DP/30: War Horse, Janusz Kaminski, Michael Ka...
Steven Spielberg's below-the-line team on War Horse: Cinematographer J...
Duration:
36m 52s
A Deep Dive into the mind of: Michael Kahn
We take a look into the bios and history of one the most renowned film...
Duration:
15m 10s
Steven Spielberg and A.C.E Film Editor Michae...
Legendary A.C.E Film Editor Michael Khan and Steven Spielberg on cutti...
Duration:
1m 58s
Editor Michael Kahn, ACE Discusses the Use of...
Manhattan Edit Workshop presents: Sight, Sound & Story - Michael Kahn,...