Michael M Kahn

US Patent:

7932384, Apr 26, 2011

Filed:

Jul 27, 2009

Appl. No.:

12/510107

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US
Soo Jin Lee - Suwon-shi, KR

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

544184, 514243

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

8101751, Jan 24, 2012

Filed:

Aug 14, 2009

Appl. No.:

12/541388

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

544184, 514243

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

8106049, Jan 31, 2012

Filed:

Sep 3, 2009

Appl. No.:

12/553858

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility as diagnostic and therapeutic agents for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis. In one embodiment, these reverse-term mimetics have a general structure of formula (VI):.

US Patent:

8138337, Mar 20, 2012

Filed:

Dec 29, 2009

Appl. No.:

12/649161

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US
Soo Jin Lee - Suwon-shi, KR

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

544184, 514243

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

8293743, Oct 23, 2012

Filed:

Nov 11, 2009

Appl. No.:

12/616712

Inventors:

Michael Kahn - Los Angeles CA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

A61K 31/495

US Classification:

514249, 544349

Abstract:

The invention provides α-mimetic structures represented by Formula (VI) and a chemical library relating thereto. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat cancer stem cells.

US Patent:

8318738, Nov 27, 2012

Filed:

Jul 29, 2011

Appl. No.:

13/194428

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Chungcheongbuk-do, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

8604018, Dec 10, 2013

Filed:

Mar 28, 2011

Appl. No.:

13/073176

Inventors:

Michael Kahn - Altadena CA, US
Masakatsu Eguchi - Bellevue WA, US

Assignee:

Institute for Chemical Genomics - Altadena CA

International Classification:

A61K 31/553
A61K 31/554
A61K 31/519

US Classification:

51421109, 5142621

Abstract:

The invention provides α-helix mimetic structures and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of diseases including fibrosis, such as pulmonary fibrosis.

US Patent:

20070128669, Jun 7, 2007

Filed:

Nov 27, 2006

Appl. No.:

11/605202

Inventors:

Michael Kahn - Los Angeles CA, US

Assignee:

Institute for Chemical Genomics - Kirkland WA

International Classification:

G01N 33/567
G01N 33/53

US Classification:

435007200

Abstract:

Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.