Michael A Kahn

US Patent:

6372744, Apr 16, 2002

Filed:

Feb 9, 2000

Appl. No.:

09/501052

Inventors:

Maher N. Qabar - Redmond WA
Michael K. McMillan - Bellevue WA
Michael S. Kahn - Kirkland WA
John E. Tulinsky - Seattle WA
Cyprian O. Ogbu - Bellevue WA
Jessymol Mathew - Bellevue WA

Assignee:

Molecumetics Ltd. - Bellevue WA

International Classification:

A61K 315025

US Classification:

514248, 514384, 530323, 530332, 5482634

Abstract:

-sheet mimetics and methods relating to the same are disclosed. The -sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a -sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.

US Patent:

6413963, Jul 2, 2002

Filed:

Dec 19, 2000

Appl. No.:

09/742682

Inventors:

Michael Kahn - Kirkland WA
Masakatsu Eguchi - Bellevue WA
Hwa-Ok Kim - Redmond WA
Marcin Stasiak - Kirkland WA

Assignee:

Molecumetics, Ltd. - Bellevue WA

International Classification:

A61K 314985

US Classification:

514249, 544279, 544350, 544 91, 540469, 540473, 540552, 540568, 435 71

Abstract:

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.

US Patent:

6440955, Aug 27, 2002

Filed:

Sep 4, 2001

Appl. No.:

09/946789

Inventors:

Marcin Stasiak - Kirkland WA
Michael Kahn - Kirkland WA

Assignee:

Molecumetics Ltd. - Bellevue WA

International Classification:

A61K 3133

US Classification:

514183, 514221, 514249

Abstract:

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R , R , R , R , R and R are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

US Patent:

6548500, Apr 15, 2003

Filed:

Dec 19, 2000

Appl. No.:

09/742680

Inventors:

Michael Kahn - Kirkland WA
Masakatsu Eguchi - Bellevue WA
Hwa-Ok Kim - Redmond WA
Marcin Stasiak - Kirkland WA

Assignee:

Molecumetics Ltd. - Bellevue WA

International Classification:

A61K 314985

US Classification:

514249, 514183, 514221, 5142305, 514825, 514826, 514903

Abstract:

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.

US Patent:

6586426, Jul 1, 2003

Filed:

Nov 18, 1999

Appl. No.:

09/443055

Inventors:

Michael Kahn - Kirkland WA

Assignee:

Molecumetics Ltd. - Richmond VA

International Classification:

A61K 31395

US Classification:

5142305, 5142288, 514359, 514368, 514369, 514413, 514464, 514221, 514562, 5142222, 562560

Abstract:

There are disclosed -sheet mimetics and methods relating to the same for imparting or stabilizing the -sheet structure of a peptide, protein or molecule. In one aspect, the -sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The -sheet mimetics have utility as protease inhibitors generally, including activity as serine protease inhibitors such as thrombin, elastase and Factor X.

US Patent:

6699869, Mar 2, 2004

Filed:

Apr 28, 2000

Appl. No.:

09/561107

Inventors:

Michael Kahn - Kirkland WA
Cyprian O. Ogbu - Bellevue WA
Masakatsu Eguchi - Bellevue WA
Hwa-Ok Kim - Redmond WA

Assignee:

Myriad Genetics Inc. - Salt Lake City UT

International Classification:

A01N 4358

US Classification:

514248, 514221, 514405, 548356, 562562

Abstract:

There are disclosed -sheet mimetics and methods relating to the same for imparting or stabilizing the -sheet structure of a peptide, protein or molecule. In one aspect, -sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the -sheet mimetic is a thrombin inhibitor.

US Patent:

6762185, Jul 13, 2004

Filed:

Mar 1, 2002

Appl. No.:

10/087005

Inventors:

Michael Kahn - Kirkland WA
Masakatsu Eguchi - Bellevue WA
Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Kwang Won Jeong - Seoul, KR

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D48704

US Classification:

514249, 544279

Abstract:

The invention involves compounds having the general formula (I) as described in the claims and pharmaceutical compositions comprising such compounds. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer.

US Patent:

7125872, Oct 24, 2006

Filed:

Dec 22, 2003

Appl. No.:

10/745471

Inventors:

Michael Kahn - Kirkland WA, US
Cyprian O. Ogbu - Bellevue WA, US
Masakatsu Eguchi - Bellevue WA, US
Hwa-Ok Kim - Redmond WA, US

Assignee:

Myriad Genetics, Inc. - Salt Lake City UT

International Classification:

A01N 43/58

US Classification:

514248, 514221, 514405, 514 19, 548356, 562562

Abstract:

There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the β-sheet mimetic is a thrombin inhibitor.