Nathan John Bryson - Toronto, CA Anthony John Giovinazzo - Oakville, CA Scott David Barnhart - York PA, US Michael Clinton Koons - York PA, US
Assignee:
ARx, LLC - Glen Rock PA Cynapsus Therapeutics, Inc. - Toronto
International Classification:
A61K 31/435 A61P 25/16 A61K 9/70
US Classification:
424443, 514284
Abstract:
The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
Scott David Barnhart - York PA, US Michael Clinton Koons - York PA, US
Assignee:
ARx, LLC - Glen Rock PA Cynapsus Therapeutics, Inc. - Toronto
International Classification:
A61K 9/70 A61K 45/06 A61K 31/473
US Classification:
514284, 424443
Abstract:
The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
Pharmaceutical Compositions With Enhanced Stability Profiles
- Warren NJ, US Rajesh Kumar Kainthan - Tappan NY, US Vincent Buono - Basking Ridge NJ, US Alexander Mark Schobel - Vero Beach FL, US Michael Koons - York PA, US Michael Goodrich - Leesburg VA, US Gregory Tsodikov - East Windsor NJ, US
- Marlborough MA, US Michael Clinton KOONS - York PA, US Madhu Sudan HARIHARAN - Greensboro NC, US Jordan DUBOW - Glencoe IL, US Thierry BILBAULT - Cambridge MA, US Anthony John GIOVINAZZO - Caledon, CA
Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an “off” episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g×mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng/mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.
Methods Of Treating Parkinson's Disease By Administration Of Apomorphine To An Oral Mucosa
- Marlborough MA, US Michael Clinton KOONS - York PA, US Madhu Sudan HARIHARAN - Greensboro NC, US Jordan DUBOW - Glencoe IL, US Thierry BILBAULT - Cambridge MA, US Anthony John GIOVINAZZO - Caledon, CA
Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an “off” episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g×mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng/mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.
The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
Methods Of Treating Parkinson's Disease By Administration Of Apomorphine To An Oral Mucosa
- Marlborough MA, US Michael Clinton Koons - York PA, US Madhu Sudan Hariharan - Greensboro NC, US Jordan Dubow - Glencoe IL, US Thierry Bilbault - Toronto, CA Anthony John Giovinazzo - Caledon, CA
Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an “off” episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g×mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng/mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.
The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
Aquestive Therapeutics
Senior Formulation Scientist
Champions Oncology, Inc.
Manager, Formulation Services
Champions Oncology, Inc. Feb 2016 - Jun 2019
Supervisor, Formulation Services
Arx, Llc Mar 2005 - Jan 2016
Senior Formulation Chemist
Arx, Llc Dec 2008 - Dec 2012
Research and Development Chemist
Education:
The Johns Hopkins University 2014 - 2018
Master of Science, Masters, Biotechnology
Lehigh University 2008 - 2011
Master of Science, Masters, Chemistry
Penn State University 2000 - 2004
Bachelors, Bachelor of Science, Molecular Biology, Biochemistry
Skills:
Formulation Gmp Chemistry Technology Transfer R&D Analytical Chemistry Product Development Quality System Validation Biotechnology Polymers Chromatography Lifesciences Polymer Chemistry Coatings Process Simulation Mass Spectrometry Capa Quality Control Hplc Materials Iso Gas Chromatography Materials Science Commercialization Laboratory Design of Experiments Chemical Engineering Characterization Fda Six Sigma V&V Process Engineering Pharmaceutical Industry Medical Devices Uv/Vis Sop Spectroscopy Lims Dissolution Adhesives Drug Delivery Wet Chemistry Pharmaceutics Regulatory Affairs Good Laboratory Practice Microsoft Office Cross Functional Team Leadership Operations Management Project Management Uv Polymer Science Differential Scanning Calorimetry Polymer Characterization Tga Physical Chemistry Plastics
Kb Home
Sales Associate
Perry Homes, Inc. Aug 2009 - Apr 2012
Sales Manager
David Weekley Homes Sep 2004 - Aug 2009
Senior Sales Consultant - Build on Your Lot
Flooring America Jan 2002 - Jul 2004
Sales Manager
Education:
Houston Community College 1984 - 1986
Houston Community College 1983 - 1986
Skills:
Negotiation New Home Sales Customer Satisfaction Real Estate Sales Residential Homes Contract Negotiation Sellers Sales Management Selling Buyers First Time Home Buyers Single Family Homes Investment Properties Referrals Customer Service Process Scheduler Real Estate Development Construction New Homes Real Estate Transactions Sales Process Land Acquisition Condos Property Management Homebuilding Marketing Account Management Relocation Resellers Buyer Representation New Home Construction Qualifying Prospects Cold Calling Luxury Commercial Real Estate Investors Listings Move Up Buyers Short Sales Property Real Property Townhomes Home Staging Vacation Homes
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Children Economic Empowerment Education Science and Technology Disaster and Humanitarian Relief Animal Welfare