Michael R Kress

US Patent:

20050119261, Jun 2, 2005

Filed:

Mar 12, 2004

Appl. No.:

10/799230

Inventors:

Prasun Chakravarty - Edison NJ, US
Michael Fisher - Ringoes NJ, US
Jeffrey Fisher - Ringoes NJ, US
Brenda Palucki - Hillsborough NJ, US
Min Park - Whippany NJ, US
William Parsons - Belle Mead NJ, US
Bishan Zhou - Hoboken NJ, US
James Carey - Downingtown PA, US
Douglas Frantz - Downingtown PA, US
Michael Kress - Exton PA, US
Damian Weaver - Lansdale PA, US

International Classification:

C07D413/02
C07D417/02
C07D043/02
A61K031/5377
A61K031/496
A61K031/506

US Classification:

514235500, 514255050, 514253050, 514256000, 514326000, 514365000, 514374000, 514364000, 514341000, 514378000, 544132000, 544333000, 544405000, 544366000, 546210000, 546272400, 548200000, 548215000, 548131000, 548240000, 548266200

Abstract:

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

US Patent:

20060183897, Aug 17, 2006

Filed:

Mar 12, 2004

Appl. No.:

10/549790

Inventors:

Prasun Chakravarty - Edison NJ, US
Michael Fisher - Ringoes NJ, US
Brenda Palucki - Hillsborough NJ, US
Min Park - Whippany NJ, US
William Parsons - Belle Mead NJ, US
Bishan Zhou - Hoboken NJ, US
James Carey - Downingtown PA, US
Douglas Frantz - Downingtown PA, US
Michael Kress - Exton PA, US
Damian Weaver - Lansdale PA, US

International Classification:

C07D 417/02
C07D 403/02
C07D 413/02

US Classification:

544132000, 544405000, 544366000, 546272400, 544333000, 546210000, 548200000, 548131000, 548215000, 548266200

Abstract:

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

US Patent:

57837090, Jul 21, 1998

Filed:

Aug 25, 1997

Appl. No.:

8/918294

Inventors:

Michael Kress - Somerset NJ
Chunhua Yang - Edison NJ
Nobuyoshi Yasuda - Mountainside NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D20716

US Classification:

548535

Abstract:

The invention encompasses a method for the stereoselective synthesis of alkyl proline and other amino acid derivatives which are intermediates of the farnesyl-protein transferase inhibiting CA. sup. 1 A. sup. 2 X motif of the protein Ras. The instant process employs an efficient diastereoselective �2,3!-Wittig rearrangement of. alpha. -allyloxy amide enolates mediated by a chiral auxiliary to provide acyclic and cyclic precursors.