Michael Leff

US Patent:

20220372098, Nov 24, 2022

Filed:

Jun 26, 2020

Appl. No.:

17/622539

Inventors:

- Baltimore MD, US
- Prague, CZ
Michael Isaac Leff - Baltimore MD, US
Seth Ludwig - Baltimore MD, US
Elissa Kathleen Leonard - Baltimore MD, US
Marek Kovár - Prague, CZ
Jirina Kovárová - Prague, CZ

International Classification:

C07K 14/55
C07K 16/24
A61P 35/00

Abstract:

This document relates to methods and materials for targeted expansion of immune effector (Eff) T cells. For example, a composition containing one or more amino acid chains (e.g., one or more single-chain antibody/cytokine fusion proteins (immunocytokines)) that can bind to a heterodimeric receptor including an interleukin-2 receptor-β (IL-2Rβ) polypeptide and a common gamma chain (γ) polypeptide (e.g., an IL-2Rβ/γpolypeptide complex) can be administered to a mammal to stimulate Effs within the mammal to activate an immune response in that mammal. In some cases, methods and materials that can be used to treat a mammal having a condition that can benefit from activating an immune response (e.g., a cancer and/or an infectious disease) are provided. For example, a composition containing one or more single-chain immunocytokines that can bind to an IL-2Rβ/γpolypeptide complex can be administered to a mammal having a cancer and/or an infectious disease to treat the mammal.