Michael C Ma

US Patent:

56022441, Feb 11, 1997

Filed:

May 8, 1995

Appl. No.:

8/436714

Inventors:

Marvin H. Caruthers - Boulder CO
Wolfgang K.-D. Brill - Schopfheim, DE
Eric Yau - Mercer Island WA
Michael Ma - New York NY
John Nielsen - Horsholm, DK

Assignee:

Competitive Technologies, Inc. - Westport CT

International Classification:

C07H 2100
C07H 1910
C07H 1920

US Classification:

536 256

Abstract:

Dinucleoside phosphorodithioate phosphoramidite precursors useful in the synthesis of oligonucleotide phosphorodithioate which can be used as antisense inhibitors of translation.

US Patent:

60571535, May 2, 2000

Filed:

Jul 14, 1997

Appl. No.:

8/892747

Inventors:

Shaji T. George - New York NY
Michael Ma - New York NY
Martina Werner - New York NY
Umberto Pace - Riverdale NY
Allan R. Goldberg - New York NY

Assignee:

Yale University - New Haven CT

International Classification:

C12N 1563
C12N 1585
C07H 2104

US Classification:

4353201

Abstract:

Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.

US Patent:

56841485, Nov 4, 1997

Filed:

May 17, 1995

Appl. No.:

8/442705

Inventors:

Marvin H. Caruthers - Boulder CO
Wolfgang K. D. Brill - Schopfheim, DE
Eric Yau - Mercer Island WA
Michael Ma - New York NY
John Nielsen - Horsholm, DK

Assignee:

Competitive Technologies, Inc. - Fairfield CT

International Classification:

C07H 1910
C07H 1920

US Classification:

536 261

Abstract:

The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.

US Patent:

56838735, Nov 4, 1997

Filed:

Jan 13, 1995

Appl. No.:

8/372556

Inventors:

Shaji T. George - New York NY
Michael Ma - Roosevelt Island NY
Martina Werner - New York NY
Umberto Pace - Riverdale NY
Allan R. Goldberg - New York NY

Assignee:

Innovir Laboratories, Inc. - New York NY

International Classification:

C12Q 168
A61K 4800
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.

US Patent:

57506663, May 12, 1998

Filed:

Oct 31, 1994

Appl. No.:

8/332829

Inventors:

Marvin H. Caruthers - Boulder CO
Wolfgang K.-D Brill - Schopfheim, DE
Eric Yau - Mercer Island WA
Michael Ma - New York NY
John Nielsen - Horsholm, DK

Assignee:

Competitve Technologies, Inc. - Fairfield CT

International Classification:

C07H 2100
C12Q 168
C12N 999
C12N 510

US Classification:

536 231

Abstract:

The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.