Michael R Mcgrath

US Patent:

6537523, Mar 25, 2003

Filed:

Nov 20, 1997

Appl. No.:

08/975532

Inventors:

Michael S. McGrath - Burlingame CA
Brian Herndier - San Francisco CA
Bruce Shiramizu - Pacifica CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 4900

US Classification:

424 92, 424 932, 435325, 435372, 435455

Abstract:

The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.

US Patent:

6703202, Mar 9, 2004

Filed:

Nov 30, 2000

Appl. No.:

09/725499

Inventors:

Michael McGrath - Burlingame CA
Stefan Meuer - Heldelberg, DE
Friedrich-Wilhelm Kuehne - Bangkok, TH

Assignee:

Oxo Chemie AG - Fribourg

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 243, 536 2432, 536 2433, 536 231

Abstract:

Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression re measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.

US Patent:

6927943, Aug 9, 2005

Filed:

Dec 21, 2001

Appl. No.:

10/027907

Inventors:

Michael C. McGrath - Pleasanton CA, US

Assignee:

Maxtor Corporation - Longmont CO

International Classification:

G11B005/54

US Classification:

3602547

Abstract:

The present invention is directed to a load/unload ramp assembly which is interconnectable with a base plate of a dynamic load/unload-type disk drive. The load/unload ramp assembly generally includes a load/unload ramp and at least one base plate attachment cantilever. A fastener shaft is directed past each of the base plate attachment cantilevers and into a fastener receptacle on the base plate. A fastener head simultaneously exerts a force on each of the base plate attachment cantilevers that are engaged by the head to deflect such base plate attachment cantilevers toward the base plate, to in turn dispose the load/unload ramp assembly in forcible engagement with the base plate.

US Patent:

7087648, Aug 8, 2006

Filed:

Oct 26, 1998

Appl. No.:

09/179383

Inventors:

Michael S. McGrath - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/13
A61K 31/655

US Classification:

514674, 514673, 514151, 514659

Abstract:

Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.

US Patent:

7105183, Sep 12, 2006

Filed:

Jan 24, 2005

Appl. No.:

11/042816

Inventors:

Michael S. McGrath - Burlingame CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 33/00
A61K 33/14
A61K 33/40
A61P 25/00
A61P 25/28
A61P 31/00

US Classification:

424661, 424613, 424615, 424662, 424663, 424665, 514885

Abstract:

The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.

US Patent:

7198946, Apr 3, 2007

Filed:

Nov 18, 2002

Appl. No.:

10/299946

Inventors:

Laurence J. Marton - Palo Alto CA, US
Tennore M. Ramesh - Westwood MA, US
Sean Scott - San Francisco CA, US
Michael McGrath - Burlingame CA, US

Assignee:

Pathologica, LLC - San Francisco CA

International Classification:

C12N 5/08
G01N 33/53
C12Q 1/02

US Classification:

435368, 435 724, 435 29

Abstract:

The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+ monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.

US Patent:

7203019, Apr 10, 2007

Filed:

Oct 5, 2005

Appl. No.:

11/243815

Inventors:

Yanning Liu - Fremont CA, US
Yanchu Xu - San Jose CA, US
Michael McGrath - Pleasanton CA, US
David Tung - Livermore CA, US
Mark Heimbaugh - Pleasanton CA, US

Assignee:

Maxtor Corporation - Longmont CO

International Classification:

G11B 21/02
G11B 21/22
G11B 5/54
G11B 5/596

US Classification:

360 75, 360256, 3602562

Abstract:

A latch apparatus is configured to latch an actuator arm assembly that can position a read/write head relative to a data storage disk in a disk drive. The latch apparatus includes a latch arm, a coil, a permanent magnet, and a latch control circuit. The latch arm is configured to be moved between a closed position that inhibits movement of the actuator arm assembly in a landing zone and an open position that does not inhibit movement of the actuator arm assembly in the landing zone. The coil is configured to generate an electromagnetic force on the latch arm responsive to a coil current. The permanent magnet is configured to generate a magnetic force on the latch arm that is substantially opposed to the electromagnetic force from the coil. The latch control circuit is configured to increase according to defined open current profiles over a defined opening time period the coil current to at least an upper defined level to cause the coil to move the latch arm from the closed position to the open position. The latch control circuit is further configured to decrease according to defined close current profiles over a defined closing time period the coil current to no more than a lower defined level to cause the permanent magnet to move the latch arm from the open position to the closed position.

US Patent:

7222411, May 29, 2007

Filed:

May 9, 2005

Appl. No.:

11/125040

Inventors:

Michael C. McGrath - Pleasanton CA, US

Assignee:

Maxtor Corporation - Scotts Valley CA

International Classification:

G11B 5/127
G11B 5/54

US Classification:

2960303, 2960304, 2952501, 2952511, 3602547

Abstract:

The present invention is directed to a load/unload ramp assembly which is interconnectable with a base plate of a dynamic load/unload-type disk drive. The load/unload ramp assembly generally includes a load/unload ramp and at least one base plate attachment cantilever. A fastener shaft is directed past each of the base plate attachment cantilevers and into a fastener receptacle on the base plate. A fastener head simultaneously exerts a force on each of the base plate attachment cantilevers that are engaged by the head to deflect such base plate attachment cantilevers toward the base plate, to in turn dispose the load/unload ramp assembly in forcible engagement with the base plate.