Michael A Mcmillan

US Patent:

20030008883, Jan 9, 2003

Filed:

Aug 6, 2001

Appl. No.:

09/922874

Inventors:

Elfrida Grant - Perrineville NJ, US
Frank Brown - Whitehouse Station NJ, US
Robert Zivin - Skillman NJ, US
Michael McMillan - Somerville NJ, US
Zhong Zhong - Bridgewater NJ, US
Malcolm Scott - Telford PA, US
Allen Reitz - Lansdale PA, US
Tina Ross - Audubon PA, US

International Classification:

A61K031/506
C 07D 4 3/02

US Classification:

514/256000, 544/296000

Abstract:

This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.

US Patent:

20050203092, Sep 15, 2005

Filed:

Nov 12, 2004

Appl. No.:

10/987562

Inventors:

Elfrida Benjamin - Englishtown NJ, US
Frank Brown - Whitehouse Station NJ, US
Robert Zivin - Skillman NJ, US
Michael McMillan - Somerville NJ, US
Zhong Zhong - Clinton NJ, US
Allen Reitz - Lansdale PA, US
Tina Ross - Royersford PA, US

International Classification:

C07D413/02
A61K031/5377
A61K031/506
C07D043/02

US Classification:

514235500, 514252140, 544122000, 544295000

Abstract:

This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.

US Patent:

45490821, Oct 22, 1985

Filed:

Apr 19, 1983

Appl. No.:

6/486526

Inventors:

Michael R. McMillan - McLean VA

International Classification:

H01J 2700

US Classification:

250423R

Abstract:

An improved crossed-beam charge-exchange ion gun in which a synthetic plasma is formed by injecting an electron beam into a collimated molecular beam just before the molecules are ionized by charge exchange with a crossed primary ion beam, thereby forming a secondary ion beam from the ionized but space-charge-neutralized and substantially undeflected molecular beam. The plasma thus formed extends to an aperture stop in an aperture tube which extends upstream from an anode downstream of which anode a cathode is placed. A field is formed within the cathode/anode space and within the aperture tube into which the plasma extends. The sheath edge of the plasma within the tube is curved by the field to form a meniscus, and the aperture, being smaller in area than the secondary ion beam upstream of the aperture, both collimates the secondary ion beam and acts as a lens stop for the subsequent immersion lens formed by the meniscus and the field region.

US Patent:

47467991, May 24, 1988

Filed:

Jul 30, 1986

Appl. No.:

6/890556

Inventors:

Michael R. McMillan - Gaithersburg MD

International Classification:

H01J 2702

US Classification:

250423R

Abstract:

A compact radiation source is obtainable by cascade ionization of a high pressure gas jet as it emerges into a vacuum. The high frequency electric field causing the ionization can be supplied by either microwave or infra-red means. The radiation produced includes ions, atoms, plasma or light, in particular, vacuum ultraviolet radiation.

US Patent:

51500671, Sep 22, 1992

Filed:

Apr 16, 1990

Appl. No.:

7/516143

Inventors:

Michael R. McMillan - Gaithersburg MD

International Classification:

H03K 304
H01J 4306

US Classification:

328 64

Abstract:

A pulse generator for producing high-energy, subnanosecond electromagnetic pulses. The generator comprises a pulsed cathode assembly (160) which includes a microchannel-plate electron multiplier (150) triggered by a low-intensity, pulsed electron beam. An intense, pulsed electron beam obtained from the cathode assembly is directed through aperture (71) in waveguiding structure (170). It generates electromagnetic pulses, which are carried by the waveguiding structure to load (130).