Michael Merchant

US Patent:

8039227, Oct 18, 2011

Filed:

Sep 19, 2008

Appl. No.:

12/234401

Inventors:

Jon B. Klein - Louisville KY, US
Michael Merchant - Louisville KY, US
Grzegorz Boratyn - Washington DC, US

Assignee:

University of Louisville Research Foundation, Inc. - Louisville KY

International Classification:

C12Q 1/02
C07K 7/00
C07K 7/18

US Classification:

435 792, 435 29, 530300, 530314, 530328, 530329

Abstract:

Methods for diagnosing a kidney disease, or the risk thereof, in a subject are provided. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.

US Patent:

8394601, Mar 12, 2013

Filed:

Sep 16, 2011

Appl. No.:

13/234756

Inventors:

Jon B. Klein - Louisville KY, US
Michael Merchant - Louisville KY, US
Grzegorz Boratyn - Louisville KY, US

Assignee:

University of Louisville Research Foundation, Inc. - Louisville KY

International Classification:

C07K 7/00
G01N 33/53
H01J 49/26
H01J 49/40

US Classification:

435 792, 530326, 530327, 530328, 530329, 5303871, 436501

Abstract:

Methods and kits are provided for diagnosing a kidney disease, or the risk thereof, in a subject. The methods include determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.

US Patent:

20090258379, Oct 15, 2009

Filed:

Apr 26, 2007

Appl. No.:

12/298467

Inventors:

Jon Klein - Louisville KY, US
Elias Klein - Louisville KY, US
Michael Merchant - Louisville KY, US

Assignee:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

International Classification:

G01N 33/00
C12N 1/00
C12Q 1/00
C07K 1/14

US Classification:

435 792, 4353171, 435 4, 530344

Abstract:

Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.

US Patent:

20100124552, May 20, 2010

Filed:

Apr 18, 2008

Appl. No.:

12/596814

Inventors:

Jon Klein - Louisville KY, US
Michael L. Merchant - Louisville KY, US
Rosemary Ouseph - Louisville KY, US
Richard A. Ward - Louisville KY, US

Assignee:

University of Louisville Research Foundation, Inc. - Louisville KY

International Classification:

A61K 39/395
G01N 33/53
G01N 33/00
C07K 16/00

US Classification:

4241391, 435 792, 436 86, 5303879

Abstract:

The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.

US Patent:

20110318761, Dec 29, 2011

Filed:

Jun 23, 2011

Appl. No.:

13/167478

Inventors:

Michael L. Merchant - Louisville KY, US
Jon B. Klein - Louisville KY, US
Michael E. Brier - New Albany IN, US
Adam E. Gaweda - Louisville KY, US

Assignee:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

International Classification:

G01N 33/566
C07K 17/00
H01J 49/26
C07K 16/18

US Classification:

435 792, 436501, 5303879, 5303911, 250282

Abstract:

Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.

US Patent:

20140243432, Aug 28, 2014

Filed:

Apr 11, 2014

Appl. No.:

14/251371

Inventors:

- Louisville KY, US
Michael L. Merchant - Louisville KY, US
Rosemary Ouseph - Louisville KY, US
Richard A. Ward - Louisville KY, US

Assignee:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

International Classification:

G01N 33/543

US Classification:

514789, 435 792, 5303879

Abstract:

The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.