Michael J Micklus

US Patent:

20020025313, Feb 28, 2002

Filed:

Feb 26, 2001

Appl. No.:

09/794719

Inventors:

Michael Micklus - Philadelphia PA, US
Nigel Greig - Silver Spring MD, US
Stanley Rapoport - Washington DC, US

International Classification:

A61K039/395
A61K009/127

US Classification:

424/130100, 424/450000

Abstract:

The present invention is directed to the targeting of drugs, peptides, and proteins to the brain. Liposomes containing the compound to be delivered are coupled to antibody binding fragments which bind to receptors on the vascular endothelium of the blood-brain barrier. The targeted receptors include transferrin receptor, insulin receptor, IGF-I and IGF-II receptors, among others. Also provided are pharmaceutical compositions and methods for administering the drugs to a subject in need by means of the receptor-targeted immunoliposomes.

US Patent:

41003098, Jul 11, 1978

Filed:

Aug 8, 1977

Appl. No.:

5/822412

Inventors:

Michael J. Micklus - Somerville NJ
David T. Ou-Yang - Raritan NJ

Assignee:

Biosearch Medical Products, Inc. - Raritan NJ

International Classification:

A61M 2300

US Classification:

427 2

Abstract:

A substrate is coated with a polyvinylpyrollidone-polyurethane interpolymer. In the method, a polyisocyanate and a polyurethane in a solvent such as methyl ethyl ketone are applied to a substrate and the solvent evaporated. If the substrate is a polyurethane, only the polyisocyanate need be employed. Polyvinylpyrollidone in a solvent is then applied to the treated substrate and the solvent evaporated. The invention is applied, for example, to a tube such as a catheter, a condom and a peristaltic pump tube.

US Patent:

41190947, Oct 10, 1978

Filed:

Mar 23, 1978

Appl. No.:

5/889249

Inventors:

Michael J. Micklus - Somerville NJ
David T. Ou-Yang - Raritan NJ

Assignee:

Biosearch Medical Products Inc. - Raritan NJ

International Classification:

A61F 542
A61M 2500

US Classification:

128132R

Abstract:

A substrate is coated with a polyvinylpyrrolidone-polyurethane interpolymer. In the method, a polyisocyanate and a polyurethane in a solvent such as methyl ethyl ketone are applied to a substrate and the solvent evaporated. If the substrate is a polyurethane, only the polyisocyanate need be employed. Polyvinylpyrrolidone in a solvent is then applied to the treated substrate and the solvent evaporated. The invention is applied, for example, to a tube such as a catheter, a condom and a peristaltic pump tube.