Michael R Napolitano

US Patent:

20220372501, Nov 24, 2022

Filed:

Sep 24, 2020

Appl. No.:

17/763152

Inventors:

- Boston MA, US
Michael G. Napolitano - Boston MA, US

Assignee:

Ginkgo Bioworks, Inc. - Boston MA

International Classification:

C12N 15/81
C12N 9/10
C12P 19/18

Abstract:

The disclosure relates to methods and compositions for the production of fructans using sucrose:sucrose 1-fructosyl-transferase (1-SST), fructan:fructan 1-fructosyltransferase (1-FFT), and/or sucrose fructan-6-fructosyltransferase (6-SFT) enzymes.

US Patent:

20220348889, Nov 3, 2022

Filed:

May 13, 2022

Appl. No.:

17/744578

Inventors:

- Boston MA, US
Jeffery Ian Boucher - Boston MA, US
Michael Gregory Napolitano - Boston MA, US

Assignee:

Ginkgo Bioworks, Inc. - Boston MA

International Classification:

C12N 9/02

Abstract:

The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.

US Patent:

20220246240, Aug 4, 2022

Filed:

Apr 13, 2022

Appl. No.:

17/719431

Inventors:

- Cambridge MA, US
Marc J. Lajoie - Cambridge MA, US
Matthieu M. Landon - Boston MA, US
Michael G. Napolitano - Brookline MA, US
Daniel Bryan Goodman - Cambridge MA, US
Christopher J. Gregg - Melrose MA, US
George M. Church - Brookline MA, US
Nili Ostrov - Brookline MA, US

International Classification:

G16B 35/10
G16B 20/50
C07K 14/245
C12N 15/10
C12P 21/00

Abstract:

Methods and systems for designing, testing, and validating genome designs based on rules or constraints or conditions or parameters or features and scoring are described herein. A computer-implemented method includes receiving data for a known genome and a list of alleles, identifying and removing occurrences of each allele in the known genome, determining a plurality of allele choices with which to replace occurrences in the known genome, generating a plurality of alternative gene sequences for a genome design based on the known genome, wherein each alternative gene sequence comprises a different allele choice, applying a plurality of rules or constraints or conditions or parameters or features to each alternative gene sequence by assigning a score for each rule or constraint or condition or parameter or feature in each alternative gene sequence, resulting in scores for the applied plurality of rules or constraints or conditions or parameters or features, scoring each alternative gene sequence based on a weighted combination of the scores for the plurality of rules or constraints or conditions or parameters or features, and selecting at least one alternative gene sequence as the genome design based on the scoring.

US Patent:

20200255809, Aug 13, 2020

Filed:

Sep 12, 2018

Appl. No.:

16/646814

Inventors:

- Boston MA, US
Jeffrey Ian Boucher - Boston MA, US
Michael Gregory Napolitano - Boston MA, US

Assignee:

Ginkgo Bioworks, Inc. - Boston MA

International Classification:

C12N 9/02

Abstract:

The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.

US Patent:

20200055903, Feb 20, 2020

Filed:

Jun 15, 2017

Appl. No.:

16/309645

Inventors:

- Cambridge MA, US
Marc J. Lajoie - Cambridge MA, US
Matthieu M. Landon - Boston MA, US
Michael G. Napolitano - Brookline MA, US
Daniel Bryan Goodman - Cambridge MA, US
Christopher J. Gregg - Melrose MA, US
George M. Church - Brookline MA, US
Nili Ostrov - Brookline MA, US

International Classification:

C07K 14/245
C12P 21/00
C12N 15/10
G16B 20/50

Abstract:

Methods and systems for designing, testing, and validating genome designs are described herein. A computer-implemented method includes receiving data for a known genome and a list of alleles, identifying and removing occurrences of each allele in the known genome, determining a plurality of allele choices with which to replace occurrences in the known genome, generating a plurality of alternative gene sequences for a genome design based on the known genome, applying a plurality of rules or constraints or conditions or parameters or features to each alternative gene sequence by assigning a score for each rule or constraint or condition or parameter or feature in each alternative gene sequence, resulting in scores, scoring each alternative gene sequence based on a weighted combination of the scores, and selecting at least one alternative gene sequence as the genome design based on the scoring.