Michael S Newman

US Patent:

6613903, Sep 2, 2003

Filed:

Jul 9, 2001

Appl. No.:

09/901367

Inventors:

Henrik Sune Andersen - Lyngby, DK
Thomas Kruse Hansen - Herlev, DK
Jesper Lau - Farum, DK
Niels Peter Hundahl Moller - Kobenhavn O, DK
Ole Hvilsted Olsen - Bronshoj, DK
Frank Urban Axe - Escondido CA
Farid Bakir - San Diego CA
Yu Ge - San Diego CA
Daniel Dale Holsworth - San Diego CA
Luke Milburn Judge - Seattle WA
Michael James Newman - San Diego CA
Roy Teruyuki Uyeda - San Diego CA
Barry Zvi Shapira - Acton CA

Assignee:

Novo Nordisk A/S - Bagsvaerd

International Classification:

C07D47102

US Classification:

546114, 514301

Abstract:

The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) including PTP1B, T cell PTP, wherein X, R , R , R , and R are defined more fully in the description. The compounds are useful in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

US Patent:

8225750, Jul 24, 2012

Filed:

Feb 18, 2010

Appl. No.:

12/658912

Inventors:

Michael Joseph Newman - Sherman Oaks CA, US

International Classification:

A01K 15/02

US Classification:

119707, 119 5101

Abstract:

A dispenser for a toy and treats and a method for using the dispenser are disclosed. The dispenser contains an enclosure having a funnel at the top, an opening at the bottom of one of the enclosure walls, a treat dispenser containing treats having at least one hole from which the treats can exit, a ramp that directs the toy and treats to exit the enclosure and a support for the funnel and treat dispenser. The pet is encouraged to drop the toy into the enclosure through the funnel. The toy bounces off the treat dispenser causing it to release treats through the hole at the bottom of the dispenser. The toy and the treats roll out the opening encouraging the pet to further interact with the dispenser for fun and exercise.

US Patent:

8257190, Sep 4, 2012

Filed:

Jun 2, 2011

Appl. No.:

13/134312

Inventors:

Michael Joseph Newman - Sherman Oaks CA, US

International Classification:

A63B 69/36
A41D 19/00

US Classification:

473205, 473212, 21613

Abstract:

According to this invention, a golf strap comprised of a flexible soft material with a visual alignment indicator and fastener is provided with a raised flexible bar across the palm portion, which aligns the golf club for proper gripping. The golf strap is worn around a golfer's hand, and the visual alignment indicator directs the golfer in proper golf strap placement before affixing the fastener to secure the golf strap. The flexible bar is so positioned across the palm portion of the golf strap that, when the golf club grip is held, the gripping hand of a golfer wearing the golf strap receives the grip portion of the club shaft across the palm of the golf strap and against the flexible bar. The flexible bar positions the club shaft to lie diagonally across the roots of the fingers. When the hand is closed around the golf club, with the flexible bar cradling the grip portion of the golf club, an automatic proper gripping of the golf club will be ensured.

US Patent:

8613675, Dec 24, 2013

Filed:

Aug 2, 2012

Appl. No.:

13/565649

Inventors:

Michael Joseph Newman - Sherman Oaks CA, US

International Classification:

A63B 69/36

US Classification:

473205, 473212, 473409, 21613

Abstract:

A strap comprised of a flexible soft material has a raised flexible bar across the palm portion, which aligns a sporting apparatus for proper gripping. The strap is worn around the hand, and a visual alignment indicator can direct the user in proper strap placement before affixing the fastener to secure the strap.

US Patent:

20020099073, Jul 25, 2002

Filed:

Jul 9, 2001

Appl. No.:

09/901284

Inventors:

Henrik Andersen - Lyngby, DK
Thomas Hansen - Herlev, DK
Jesper Lau - Farum, DK
Niels Moller - Kobenhavn O, DK
Ole Olsen - Bronshoj, DK
Frank Axe - Escondido CA, US
Farid Bakir - San Diego CA, US
Yu Ge - San Diego CA, US
Daniel Holsworth - San Diego CA, US
Luke Judge - Seattle WA, US
Michael Newman - San Diego CA, US
Roy Uyeda - San Diego CA, US
Barry Shapira - Acton CA, US

International Classification:

C07D498/02
A61K031/4743

US Classification:

514/301000, 546/114000

Abstract:

The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP (TC-PTP), wherein X, R, R, R, and Rare defined more fully in the description. The compounds are useful in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

US Patent:

20020147197, Oct 10, 2002

Filed:

Mar 20, 2002

Appl. No.:

10/104549

Inventors:

Michael Newman - San Diego CA, US
William Dixon - La Jolla CA, US

International Classification:

A61K031/5377
A61K031/454
A61K031/4178

US Classification:

514/235800, 514/254050, 514/326000, 514/396000, 514/397000, 514/400000

Abstract:

Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.

US Patent:

20050148534, Jul 7, 2005

Filed:

Sep 22, 2004

Appl. No.:

10/948364

Inventors:

Angelo Castellino - San Diego CA, US
Carlo Ballatore - San Diego CA, US
Simon Aspland - San Diego CA, US
Joel Desharnais - San Diego CA, US
Michael Newman - San Diego CA, US
Chengzao Sun - San Diego CA, US
Peter Wirsching - San Diego CA, US

International Classification:

A61K048/00
A61K031/7076
A61K031/7072
A61K031/522
A61K031/513

US Classification:

514044000, 514045000, 514049000, 514263240, 514269000, 514063000, 514151000, 514081000, 514084000, 536027100, 536028100, 544243000, 544244000, 544269000, 544309000

Abstract:

In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S  (1) or formula 2: D-L-S′  (2) wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S′ is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.

US Patent:

20050187147, Aug 25, 2005

Filed:

Sep 22, 2004

Appl. No.:

10/948707

Inventors:

Michael Newman - San Diego CA, US
Angelo Castellino - San Diego CA, US
Joel Desharnais - San Diego CA, US
Zijian Guo - San Diego CA, US
Qing Li - San Diego CA, US
Carlo Ballatore - San Diego CA, US
Chengzao Sun - San Diego CA, US

International Classification:

A61K038/14
A61K038/08
C07K007/08

US Classification:

514008000, 514015000, 530322000, 530328000, 530329000

Abstract:

In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.