James Stefano - Hopkinton MA, US Clark Pan - Framingham MA, US Huawei Qiu - Framingham MA, US Michael O'Callaghan - Framingham MA, US Gloria Matthews - Framingham MA, US
Assignee:
Genzyem Corporation - Westborough MA
International Classification:
C07K 14/71 C12N 9/12
US Classification:
514 81, 530350, 530410, 4353201, 435 691, 435369
Abstract:
The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.
- Cambridge MA, US Clark Pan - Cambridge MA, US Huawei Qui - Cambridge MA, US Michael O'Callaghan - Cambridge MA, US Gloria Matthews - Cambridge MA, US
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
C12N 9/12 C07K 14/71
Abstract:
The invention provides compositions and methods for treating a disease or disorder associate with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.
- Concord MA, US Michael O'Callaghan - Sherborn MA, US Alan H. Beggs - Needham MA, US Michael W. Lawlor - Elm Grove WI, US
International Classification:
C07K 16/18 C12N 9/16
Abstract:
The present disclosure provides methods for increasing muscle contractility in a myotubular myopathy subject following administration of fewer than 20 doses of a chimeric polypeptide that has a myotubularin protein and an internalizing moiety.