Michael J O'Hara

US Patent:

20090035347, Feb 5, 2009

Filed:

Mar 6, 2008

Appl. No.:

12/043903

Inventors:

Darwin J. Prockop - New Orleans LA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

THOMAS JEFFERSON UNIVERSITY - Philadelphia PA

International Classification:

A61K 35/28
A61K 48/00
A61F 2/02
C12N 11/00
A61P 9/00
A61P 19/00
A61P 11/00

US Classification:

424423, 424 937, 424 9321, 424549, 435174

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20100008964, Jan 14, 2010

Filed:

Mar 4, 2009

Appl. No.:

12/397718

Inventors:

Darwin J. Prockop - New Orleans LA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

THOMAS JEFFERSON UNIVERSITY - Philadelphia PA

International Classification:

A61K 9/00
A61K 45/00
C12N 5/10
A61P 35/00

US Classification:

424422, 424 937, 424 9321, 435325

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.