Michael James Phelps

US Patent:

7329401, Feb 12, 2008

Filed:

Jan 10, 2003

Appl. No.:

10/341316

Inventors:

Tatsushi Toyokuni - Sherman Oaks CA, US
Harvey R. Herschman - Los Angeles CA, US
Michael E. Phelps - Encino CA, US
Jorge R. Barrio - Agoura Hills CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 181, 424 111, 424 165, 424 185, 424 189

Abstract:

This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

US Patent:

8206593, Jun 26, 2012

Filed:

Dec 5, 2005

Appl. No.:

11/792168

Inventors:

Chung-cheng Lee - Irvine CA, US
Guodong Sui - Los Angeles CA, US
Arkadij Elizarov - Valley Village CA, US
Hartmuth C. Kolb - Playa del Rey CA, US
Jiang Huang - San Jose CA, US
James R. Heath - South Pasadena CA, US
Michael E. Phelps - Los Angeles CA, US
Stephen R. Quake - Stanford CA, US
Paul Wyatt - Tipperary, IE
Antoine Daridon - Mont-Sur-Rolle, CH

Assignee:

Fluidigm Corporation - So. San Francisco CA
California Institute of Technology - Pasadena CA
The Regents of the University of California - Oakland CA
Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

B01D 11/00
B01J 7/00
B01D 15/00

US Classification:

210640, 210634, 422129, 422134

Abstract:

New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

US Patent:

58615032, Jan 19, 1999

Filed:

Apr 30, 1997

Appl. No.:

8/846424

Inventors:

Jorge R. Barrio - Agoura Hills CA
Mohammad Namavari - Los Angeles CA
Michael E. Phelps - Encino CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 1916
C07D47300

US Classification:

536 2711

Abstract:

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F. sub. 2 in He or other inert gas.

US Patent:

62622544, Jul 17, 2001

Filed:

Nov 25, 1998

Appl. No.:

9/199975

Inventors:

Jorge R. Barrio - Agoura Hills CA
Mohammad Namavari - Los Angeles CA
Michael E. Phelps - Encino CA

Assignee:

The Regents of Univ. of California - Oakland CA

International Classification:

C07H 19167
C07H 19173
C07D47300

US Classification:

536 2711

Abstract:

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F. sub. 2 in He or other inert gas.