Michael R Press

US Patent:

7371840, May 13, 2008

Filed:

Jan 8, 2003

Appl. No.:

10/339738

Inventors:

Michael F. Press - Redondo Beach CA, US
Bahman Saffari - Yorba Linda CA, US

Assignee:

The University of Southern California - Los Angeles CA

International Classification:

C07H 21/04

US Classification:

536 235, 4353201, 435325, 435372, 530350

Abstract:

This invention provides an isolated polynucleotide encoding an ECA1 polypeptide. Also provided is the isolated ECA1 polypeptide Further provided is an antibody that specifically recognizes and binds the ECA1 polypeptide or an epitope thereof. The polynucleotides, antibodies and/or polypeptides of this invention may be components of compositions, host cells and/or gene delivery vehicles, where appropriate. In one aspect, the host cell will produce recombinant ECA1, which is further defined herein. In another aspect, the host cell is an antigen presenting cell such as a dendritic cell, and it will display an antigenic portion of the ECA1 polypeptide on its surface. The polypeptides, proteins and compositions of this invention are useful to aid in the diagnosis of a neoplastic condition of a cell of endometrioid origin. In one aspect, the method comprises detecting the presence of an overexpressed ECA1 proto-oncogene in a sample suspected of containing said cell, wherein said overexpression is indicative of the neoplastic condition of said cell. These neoplastic cells include, but are not limited to ovarian and colon carcinoma cells.

US Patent:

RE44024, Feb 19, 2013

Filed:

May 13, 2010

Appl. No.:

12/779699

Inventors:

Michael F. Press - Redondo Beach CA, US
Bahman Saffari - Yorba Linda CA, US

Assignee:

The University of Southern California - Los Angeles CA

International Classification:

C07H 21/04
A61K 39/00

US Classification:

5303879, 4353201, 435328, 435331, 435372, 530350, 5303873, 5303913, 536 235, 4241851, 4241921

Abstract:

This invention provides an isolated polynucleotide encoding an ECA1 polypeptide. Also provided is the isolated ECA1 polypeptide Further provided is an antibody that specifically recognizes and binds the ECA1 polypeptide or an epitope thereof. The polynucleotides, antibodies and/or polypeptides of this invention may be components of compositions, host cells and/or gene delivery vehicles, where appropriate. In one aspect, the host cell will produce recombinant ECA1, which is further defined herein. In another aspect, the host cell is an antigen presenting cell such as a dendritic cell, and it will display an antigenic portion of the ECA1 polypeptide on its surface. The polypeptides, proteins and compositions of this invention are useful to aid in the diagnosis of a neoplastic condition of a cell of endometrioid origin. In one aspect, the method comprises detecting the presence of an overexpressed ECA1 proto-oncogene in a sample suspected of containing said cell, wherein said overexpression is indicative of the neoplastic condition of said cell. These neoplastic cells include, but are not limited to ovarian and colon carcinoma cells.

US Patent:

58467491, Dec 8, 1998

Filed:

Oct 12, 1994

Appl. No.:

8/321688

Inventors:

Dennis J. Slamon - Woodland Hills CA
Michael F. Press - Manhattan Beach CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 3353
G01N 33574

US Classification:

435 723

Abstract:

Cellular components are quantitated using stained cell samples, computerized image analysis, and cellular standards, where the computerized image analysis value can be translated into the amount of the component per cell. The methodology is demonstrated with breast cancer cells and quantitation of the HER-2/neu gene. The quantitation is shown to have prognostic capability as to the future course of the disease.