Michael W Rasmussen

US Patent:

6576763, Jun 10, 2003

Filed:

Apr 17, 2000

Appl. No.:

09/550554

Inventors:

Per Engelhardt - Sotckholm, SE
Marita Hogberg - Tullinge, SE
Nils-Gunnar Johansson - Enhorna, SE
Xiao-Xiong Zhou - Huddinge, SE
Bjorn Lindborg - Bjornlunda, SE
M. Robert Leanna - Grayslake IL
Michael Rasmussen - Kenosha WI

Assignee:

Medivir AB - Huddinge

International Classification:

C07D47300

US Classification:

544277, 544276, 514261

Abstract:

Compounds of the Formula I where one of R and R is âC(O)CH(CH(CH ) )NH or âC(O)CH(CH(CH )CH CH )NH ; the other of R and R is âC( O)C -C saturated or monounsaturated, optionally substituted alkyl; and R is OH or H; and pharmaceutically acceptable salts thereof have utility as enhanced bioavailability antivirals against herpes and retroviral infections.

US Patent:

6613936, Sep 2, 2003

Filed:

Oct 18, 2000

Appl. No.:

09/692599

Inventors:

M. Robert Leanna - Grayslake IL
Steven M. Hannick - Highland Park IL
Michael Rasmussen - Kenosha WI
Howard Morton - Gurnee IL
Daniel Plata - Wadsworth IL

Assignee:

Medivir AB - Huddinge

International Classification:

C07C 6900

US Classification:

560129, 560231

Abstract:

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R and R is an amino acid acyl group and the other of R and R is a âC(O)C -C saturated or monounsaturated, optionally substituted alkyl and R is OH or H; or a pharmaceutically acceptable salt thereof.

US Patent:

6878844, Apr 12, 2005

Filed:

Dec 9, 2002

Appl. No.:

10/315580

Inventors:

M. Robert Leanna - Grayslake IL, US
Michael Rasmussen - Kenosha WI, US
Howard Morton - Gurnee IL, US
Zhenping Tian - Grayslake IL, US
Daniel Plata - Wadsworth IL, US
Bradley D. Gates - Mount Prospect IL, US
Bikshandarkoil A. Narayanan - Mundelein IL, US

Assignee:

Medivir AB - Huddinge

International Classification:

C07C069/00

US Classification:

560129, 560179, 560231

Abstract:

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of Rand Ris an amino acid acyl group and the other of Rand Ris a —C(O)C-Csaturated or monounsaturated, optionally substituted alkyl and Ris OH or H; or a pharmaceutically acceptable salt thereof.

US Patent:

7189849, Mar 13, 2007

Filed:

May 18, 2005

Appl. No.:

11/131646

Inventors:

M. Robert Leanna - Grayslake IL, US
Michael Rasmussen - Kenosha WI, US
Steven M. Hannick - Highland Park IL, US
Kirill A. Lukin - Mundelein IL, US
Zhenping Tian - Grayslake IL, US
Cynthia B. Curty - Gurnee IL, US
Bikshandarkoil A. Narayanan - Mundelein IL, US
John Bellettini - Waukegan IL, US
Bhadra Shelat - Lake Forest IL, US
Tiffany Spitz - Highland Park IL, US

Assignee:

Medivir AB - Huddinge

International Classification:

C07D 473/18
C07D 473/40
C07F 7/18
C07C 69/66

US Classification:

544276

Abstract:

Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

US Patent:

20040132749, Jul 8, 2004

Filed:

Dec 19, 2003

Appl. No.:

10/741615

Inventors:

Per Engelhardt - Stockholm, SE
Marita Hogberg - Tullinge, SE
Nils-Gunnar Johansson - Enhorna, SE
Xiao-Xiong Zhou - Huddinge, SE
Bjorn Lindborg - Bjornlunda, SE
M. Leanna - Grayslake IL, US
Michael Rasmussen - Kenosha WI, US

Assignee:

Medivir AB - Huddinge

International Classification:

A61K031/522
A61K031/655

US Classification:

514/263380, 544/276000, 514/151000

Abstract:

Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of Rand Ris an amino acid acyl group and the other of Rand Ris a —C(O)C—Csaturated or monounsaturated, optionally substituted alkyl and Ris OH or H.

US Patent:

20040248910, Dec 9, 2004

Filed:

Jun 17, 2004

Appl. No.:

10/871751

Inventors:

M. Leanna - Grayslake IL, US
Steven Hannick - Highland Park IL, US
Michael Rasmussen - Kenosha WI, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Pulla Singam - Des Plaines IL, US
Bradley Gates - Mount Prospect IL, US
Lawrence Kolaczkowski - Gurnee IL, US
Ramesh Patel - Chicago IL, US
Greg Wayne - Vernon Hills IL, US
Greg Lannoye - Wildwood IL, US
Weijiang Zhang - Grayslake IL, US
Zhenping Tian - Grayslake IL, US
Kirill Lukin - Mundelein IL, US
Bikshandarkoil Narayanan - Mundelein IL, US
David Riley - Kenosha WI, US
Howard Morton - Gurnee IL, US
Cynthia Curty - Gurnee IL, US
Daniel Plata - Wadsworth IL, US
John Bellettini - Waukegan IL, US
Bhadra Shelat - Lake Forest IL, US
Tiffany Spitz - Highland Park IL, US

Assignee:

Medivir AB - Huddinge

International Classification:

A61K031/522
C07D487/12

US Classification:

514/263380, 544/276000

Abstract:

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of Rand Ris an amino acid acyl group and the other of Rand Ris a —C(O)C-Csaturated or monounsaturated, optionally substituted alkyl and Ris OH or H; or a pharmaceutically acceptable salt thereof.

US Patent:

61843768, Feb 6, 2001

Filed:

Aug 6, 1998

Appl. No.:

9/130214

Inventors:

M. Robert Leanna - Grayslake IL
Steven M. Hannick - Highland Park IL
Michael Rasmussen - Kenosha WI
Lakshmi Bhagavatula - Vernon Hills IL
Pulla Reddy Singam - Des Plaines IL
Bradley D. Gates - Mount Prospect IL
Lawrence Kolaczkowski - Gurnee IL
Ramesh R. Patel - Chicago IL
Greg Wayne - Vernon Hills IL
Greg Lannoye - Wildwood IL
Weijiang Zhang - Grayslake IL
Zhenping Tian - Grayslake IL
Kirill A. Lukin - Mundelein IL
Bikshandarkoil A. Narayanan - Mundelein IL
David A. Riley - Kenosha WI
Howard Morton - Gurnee IL
Cynthia B. Curty - Gurnee IL
Daniel Plata - Wadsworth IL
John Bellettini - Waukegan IL
Bhadra Shelat - Lake Forest IL
Tiffany Spitz - Highland Park IL

Assignee:

Mediver AB - Huddinge

International Classification:

C07D47318
C07D47340
C07D31730
C07F 718
C12P 1718

US Classification:

544229

Abstract:

Methods and novel intermediates of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are lower alkyl or benzyl or R. sub. 6 and R. sub. 7 taken together are --CH. sub. 2 CH. sub. 2 --, --CH. sub. 2 CH. sub. 2 CH. sub. 2 -- or --CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 --, R. sub. 8 is C. sub. 1 -C. sub. 21 alkyl or a C. sub. 2 -C. sub. 21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkoxy, C. sub. 1 -C. sub. 6 alkoxy C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R. sub. 9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: ##STR2## where one of R. sub. 1 and R. sub.

US Patent:

20170304873, Oct 26, 2017

Filed:

Apr 20, 2017

Appl. No.:

15/492254

Inventors:

- DENVER CO, US
ADAM BEARUP - LAKEWOOD CO, US
TRENT GARNER - HIGHLANDS RANCH CO, US
SHERI HUTHER - WESTMINSTER CO, US
MICHAEL RASMUSSEN - DENVER CO, US

Assignee:

KARCHER NORTH AMERICA, INC. - DENVER CO

International Classification:

B08B 3/02
B05B 7/24
B05B 7/00
B05B 7/24

Abstract:

An electric pressure washer includes an electric motor operably connected to a pump, one or more removable detergent tanks, a removable accessory bucket in which a spray gun, high pressure hose, and other accessories may be stored, and a foot pedal for facilitating operator control of one or more features of the electric pressure washer during use. The electric pressure washer may also include a folding handle for facilitating storage and transport.