Michael Leon Rice

US Patent:

6410226, Jun 25, 2002

Filed:

Sep 11, 1997

Appl. No.:

08/927165

Inventors:

Eric B. Kmiec - Yardley PA
William K. Holloman - Yorktown Heights NY
Michael C. Rice - Newtown PA
Sheryl T. Smith - Bryn Mar PA
Zhigang Shu - Bensalem PA

Assignee:

Thomas Jefferson University - Philadelphia PA
Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 231, 536 243

Abstract:

The invention concerns mammalian recombinase genes (REC2) and their promoters. Over expression of REC2 in a cell is found to facilitate homologous recombination, particularly homologous recombination using a DNA/RNA chimeric oligonucleotide and to sensitize a cell to the apoptotic effects of irradiation. The REC2 promoter, in combination with a strong enhancer, e. g. , a SV40 enhancer, was found to be a strong promoter following irradiation of the cells. A radiation induceable promoter can be used to sensitize a cell to radiation treatment by operably linking the radiation induceable promoter to a gene whose expression converts a prodrug to a drug such as a herpes thymidien kinase gene.

US Patent:

20230071593, Mar 9, 2023

Filed:

Aug 28, 2021

Appl. No.:

17/460220

Inventors:

Michael Arthur Rice - Oldsmar FL, US

International Classification:

H02G 3/12
F16B 2/20

Abstract:

(1) The new work to old work electrical box clips are for installing a nail on box into drywall to be used as an old work electrical box by removing the nails and nail holders for a smooth surface, the old work box clips fasten the electrical box into drywall firmly and securely.(2) Older types of old work cut in boxes are currently limited in supply and many jobs can not be completed without this product. Older types of old work boxes cost more and are limited to specific manufactures designs.(3) Also the old work box clips take and use an overstock of a product, the nail on box for new construction. The clips can be made of many types of materials readily available to be manufactured and if there is a shortage of the current cut-in boxes this will solve the shortage problem by offering a different way of doing the same installation.