Michael Anthony Rice

US Patent:

6410226, Jun 25, 2002

Filed:

Sep 11, 1997

Appl. No.:

08/927165

Inventors:

Eric B. Kmiec - Yardley PA
William K. Holloman - Yorktown Heights NY
Michael C. Rice - Newtown PA
Sheryl T. Smith - Bryn Mar PA
Zhigang Shu - Bensalem PA

Assignee:

Thomas Jefferson University - Philadelphia PA
Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 231, 536 243

Abstract:

The invention concerns mammalian recombinase genes (REC2) and their promoters. Over expression of REC2 in a cell is found to facilitate homologous recombination, particularly homologous recombination using a DNA/RNA chimeric oligonucleotide and to sensitize a cell to the apoptotic effects of irradiation. The REC2 promoter, in combination with a strong enhancer, e. g. , a SV40 enhancer, was found to be a strong promoter following irradiation of the cells. A radiation induceable promoter can be used to sensitize a cell to radiation treatment by operably linking the radiation induceable promoter to a gene whose expression converts a prodrug to a drug such as a herpes thymidien kinase gene.

US Patent:

7603316, Oct 13, 2009

Filed:

May 31, 2005

Appl. No.:

10/908904

Inventors:

John P Fife - Scottsdale AZ, US
Lawrence S. Hoffman - Scottsdale AZ, US
Rafael T Perez - Glendale AZ, US
Michael E Rice - Phoenix AZ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06Q 40/00

US Classification:

705 44, 705 14

Abstract:

The present invention provides major improvement with respect to electronic transaction reporting and processing by providing advance asynchronous confirmation of a transaction to a consumer while a proxy system processes the consumer submitted transaction through to completion or failure through synchronous handoff, persistent retry logic, and exception processing.

US Patent:

51870991, Feb 16, 1993

Filed:

May 15, 1991

Appl. No.:

7/702102

Inventors:

Michael L. Rice - North Miami Beach FL
Martin L. Golick - Miami FL

Assignee:

Coulter Corporation - Hialeah FL

International Classification:

G01N 3100

US Classification:

436 10

Abstract:

A control slide for use in an immunoassay having a section of a cell pellet retained on the slide in a stable and substantially permanent formation which can be stored at room temperature. Further, the invention includes the method of making the control slide.

US Patent:

61746940, Jan 16, 2001

Filed:

Sep 21, 1998

Appl. No.:

9/157603

Inventors:

Pamela A. Havre - Philadelphia PA
Michael C. Rice - Newtown PA
William K. Holloman - Yorktown Heights NY
Eric B. Kmiec - Yardley PA

Assignee:

Thomas Jefferson University - Philadelphia PA
Cornell Research Foundation, Inc. - Ithaca NY
Valigen (US), Inc. - Newtown PA

International Classification:

C12Q 148
C12N 912

US Classification:

435 15

Abstract:

The invention includes a method of phosphorylating a serine containing substrate by incubating the substrate with ATP and an enzyme that is hsRec2 or muRec2 or a derivative thereof. The natural substrates of the kinase activity of Rec2 are the cell cycle control proteins such as p53 and cyclin E. The over expression of Rec2 is known to cause cell-cycle arrest and apoptosis and the invention discloses that these effects are kinase mediated. Accordingly, the invention provides a method of assessing antagonists and agonists of Rec2, which antagonists and agonists would have pharmacological activity. The invention further discloses that there is specific binding between hsRec2 and at least three cell cycle control proteins: p53, PCNA and cdc2.

US Patent:

48164100, Mar 28, 1989

Filed:

Oct 29, 1986

Appl. No.:

6/925617

Inventors:

Stephen F. Healy - Miami FL
Michael L. Rice - North Miami Beach FL
Martin L. Golick - Miami FL

Assignee:

Coulter Corporation - Hialeah FL

International Classification:

G01N 3100

US Classification:

436 10

Abstract:

A control slide for use in an immunoassay having a section of a cell pellet retained on the slide in a stable and substantially permanent formation which can be stored at room temperature. Further, the invention includes the method of making the control slide.

US Patent:

62109162, Apr 3, 2001

Filed:

Jun 5, 2000

Appl. No.:

9/587436

Inventors:

Pamela A. Havre - Philadelphia PA
Michael C. Rice - Newtown PA
William K. Holloman - Yorktown Heights NY
Eric B. Kmiec - Yardley PA

Assignee:

Thomas Jefferson University - Philadelphia PA
Cornell Research Foundation Inc. - Ithaca NY
Valigen (US), Inc. - Newtown PA

International Classification:

C12Q 148
C12N 912
C07K 100

US Classification:

435 15

Abstract:

The invention includes a method of phosphorylating a serine containing substrate by incubating the substrate with ATP and an enzyme that is hsRec2 or muRec2 or a derivative thereof. The natural substrates of the kinase activity of Rec2 are the cell cycle control proteins such as p53 and cyclin E. The over expression of Rec2 is known to cause cell-cycle arrest and apoptosis and the invention discloses that these effects are kinase mediated. Accordingly, the invention provides a method of assessing antagonists and agonists of Rec2, which antagonists and agonists would have pharmacological activity. The invention further discloses that there is specific binding between hsRec2 and at least three cell cycle control proteins: p53, PCNA and cdc2.