Michael J Rosen

US Patent:

20210403986, Dec 30, 2021

Filed:

May 18, 2021

Appl. No.:

17/323834

Inventors:

- Redwood City CA, US
Lily BLAIR - Redwood City CA, US
Timothy A. BLAUWKAMP - Redwood City CA, US
Peter J. EUGSTER - Redwood City CA, US
Desiree HOLLEMON - Redwood City CA, US
David K. HONG - Redwood City CA, US
Trupti KAWLI - Redwood City CA, US
Mark Alec KOWARSKY - Redwood City CA, US
Martin M.S. LINDNER - Redwood City CA, US
Michael J. ROSEN - Redwood City CA, US
Damek SPACEK - Redwood City CA, US
Igor D. VILFAN - Redwood City CA, US

Assignee:

KARIUS, INC. - Redwood City CA

International Classification:

C12Q 1/689
C12Q 1/70
C12Q 1/6806
C12Q 1/6883

Abstract:

Provided herein are fragment length profiles of nucleic acid libraries, methods of generating fragment length profiles of nucleic acid libraries and methods of using fragment length profiles for diagnostics and/or prognostics. The application further provides methods, compositions and kits for determining the infection stage or the site of localization in a subject.

US Patent:

20210324467, Oct 21, 2021

Filed:

Jun 23, 2021

Appl. No.:

17/355882

Inventors:

- Redwood City CA, US
Igor D. Vilfan - East Palo Alto CA, US
Michael Kertesz - Menlo Park CA, US
Timothy A. Blauwkamp - Palo Alto CA, US
Michael Rosen - Palo Alto CA, US
Rene Sit - Sunnyvale CA, US

International Classification:

C12Q 1/6874
G16B 30/00
C12Q 1/6869
G16B 30/10
C12N 15/10
C12Q 1/689

Abstract:

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.

US Patent:

20200291457, Sep 17, 2020

Filed:

May 27, 2020

Appl. No.:

16/884343

Inventors:

- Redwood City CA, US
Liza HUIJSE - Redwood City CA, US
Michael ROSEN - Redwood City CA, US
Igor D. VILFAN - Redwood City CA, US

Assignee:

KARIUS, INC. - Redwood City CA

International Classification:

C12Q 1/6806
C12Q 1/6869
G06F 17/18
C12Q 1/6895

Abstract:

This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.

US Patent:

20190256891, Aug 22, 2019

Filed:

Jan 31, 2019

Appl. No.:

16/263074

Inventors:

- Redwood City CA, US
Fred CHRISTIANS - Los Altos Hills CA, US
Michael ROSEN - Palo Alto CA, US
Igor D. VILFAN - East Palo Alto CA, US

International Classification:

C12Q 1/6806
C12Q 1/6848
C12Q 1/6869
C12Q 1/6876

Abstract:

This disclosure provides methods that are useful for reducing or inactivating contaminant nucleic acids.

US Patent:

20190043239, Feb 7, 2019

Filed:

Sep 28, 2018

Appl. No.:

16/146710

Inventors:

- Santa Clara CA, US
Matthew Pickett - San Francisco CA, US
Michael Rosen - San Jose CA, US
Dipika Jain - San Jose CA, US
Adelle Lin - Hillsboro OR, US

International Classification:

G06T 13/20
G10L 19/00
G06T 13/40
G06N 99/00

Abstract:

Methods, apparatus, systems and articles of manufacture are disclosed for generating an audiovisual response for an avatar. An example method includes converting a first digital signal representative of first audio including a first tone, the first digital signal incompatible with a model, to a plurality of binary values representative of a first characteristic value of the first tone, the plurality of binary values compatible with the model, selecting one of a plurality of characteristic values associated with a plurality of probability values output from the model, the probability values incompatible for output via a second digital signal representative of second audio, as a second characteristic value associated with a second tone to be included in the second audio, the second characteristic value compatible for output via the second digital signal, and controlling the avatar to output an audiovisual response based on the second digital signal and a first response type.

US Patent:

20180237851, Aug 23, 2018

Filed:

Apr 16, 2018

Appl. No.:

15/953822

Inventors:

- Redwood City CA, US
Igor D. Vilfan - East Palo Alto CA, US
Michael Kertesz - Menlo Park CA, US
Timothy A. Blauwkamp - Palo Alto CA, US
Michael Rosen - Palo Alto CA, US
Rene Sit - Sunnyvale CA, US

International Classification:

C12Q 1/6874
C12Q 1/689
C12N 15/10
G06F 19/22

Abstract:

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.

US Patent:

20170275691, Sep 28, 2017

Filed:

Mar 24, 2017

Appl. No.:

15/469474

Inventors:

- Menlo Park CA, US
Igor D. Vilfan - East Palo Alto CA, US
Michael Kertesz - Menlo Park CA, US
Timothy A. Blauwkamp - Palo Alto CA, US
Michael Rosen - Palo Alto CA, US
Rene Sit - Sunnyvale CA, US

International Classification:

C12Q 1/68
G06F 19/22
C12N 15/10

Abstract:

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.