Michael L Rosen

US Patent:

7127408, Oct 24, 2006

Filed:

Jun 13, 2003

Appl. No.:

10/461523

Inventors:

Michael J. Rosen - Miami FL, US

International Classification:

G01C 21/34

US Classification:

705 6, 705 8, 705 1

Abstract:

A method of selling season tickets is disclosed in which unrelated purchasers may reserve a seat ticket for one or more selected events in a related series of events. When enough seat tickets have been reserved, a season ticket for that seat is sold, and the individual tickets reserved for each purchaser are paid for and delivered to the purchasers. Provisions for canceling previously made reservations are included. The method is effectuated on one or more computers, and the computers may be connected to a computer network, including the internet, to allow use of the system by prospective purchasers at remote locations.

US Patent:

20200171067, Jun 4, 2020

Filed:

Mar 23, 2017

Appl. No.:

16/087788

Inventors:

- New York NY, US
- Albany NY, US
Michael R. ROSEN - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY
The Research Foundation for the State University of New York - Albany NY

International Classification:

A61K 31/713
A61K 31/7105
A61K 35/28
C12N 15/113

Abstract:

A method of treating cancer in vivo includes introducing in vitro into human mesenchymal stem cells (hMSCs) at least one type of inhibitory oligonucleotide, and contacting a tumor tissue of syncytial cancer cells with the hMSCs in vivo under conditions permitting a hMSC to form a gap junction channel with a first syncytial cancer cell of the tumor tissue. As a result, the at least one type of inhibitory oligonucleotide is delivered into the first syncytial cancer cell by traversing the gap junction channel and the at least one type of inhibitory oligonucleotide is delivered into a second syncytial cancer cell of the tumor tissue by traversing a gap junction channel between the first syncytial cancer cell and the second syncytial cancer cell.