Michael S Rosen

US Patent:

20210403986, Dec 30, 2021

Filed:

May 18, 2021

Appl. No.:

17/323834

Inventors:

- Redwood City CA, US
Lily BLAIR - Redwood City CA, US
Timothy A. BLAUWKAMP - Redwood City CA, US
Peter J. EUGSTER - Redwood City CA, US
Desiree HOLLEMON - Redwood City CA, US
David K. HONG - Redwood City CA, US
Trupti KAWLI - Redwood City CA, US
Mark Alec KOWARSKY - Redwood City CA, US
Martin M.S. LINDNER - Redwood City CA, US
Michael J. ROSEN - Redwood City CA, US
Damek SPACEK - Redwood City CA, US
Igor D. VILFAN - Redwood City CA, US

Assignee:

KARIUS, INC. - Redwood City CA

International Classification:

C12Q 1/689
C12Q 1/70
C12Q 1/6806
C12Q 1/6883

Abstract:

Provided herein are fragment length profiles of nucleic acid libraries, methods of generating fragment length profiles of nucleic acid libraries and methods of using fragment length profiles for diagnostics and/or prognostics. The application further provides methods, compositions and kits for determining the infection stage or the site of localization in a subject.

US Patent:

20210324467, Oct 21, 2021

Filed:

Jun 23, 2021

Appl. No.:

17/355882

Inventors:

- Redwood City CA, US
Igor D. Vilfan - East Palo Alto CA, US
Michael Kertesz - Menlo Park CA, US
Timothy A. Blauwkamp - Palo Alto CA, US
Michael Rosen - Palo Alto CA, US
Rene Sit - Sunnyvale CA, US

International Classification:

C12Q 1/6874
G16B 30/00
C12Q 1/6869
G16B 30/10
C12N 15/10
C12Q 1/689

Abstract:

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.

US Patent:

20200291457, Sep 17, 2020

Filed:

May 27, 2020

Appl. No.:

16/884343

Inventors:

- Redwood City CA, US
Liza HUIJSE - Redwood City CA, US
Michael ROSEN - Redwood City CA, US
Igor D. VILFAN - Redwood City CA, US

Assignee:

KARIUS, INC. - Redwood City CA

International Classification:

C12Q 1/6806
C12Q 1/6869
G06F 17/18
C12Q 1/6895

Abstract:

This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.

US Patent:

20190256891, Aug 22, 2019

Filed:

Jan 31, 2019

Appl. No.:

16/263074

Inventors:

- Redwood City CA, US
Fred CHRISTIANS - Los Altos Hills CA, US
Michael ROSEN - Palo Alto CA, US
Igor D. VILFAN - East Palo Alto CA, US

International Classification:

C12Q 1/6806
C12Q 1/6848
C12Q 1/6869
C12Q 1/6876

Abstract:

This disclosure provides methods that are useful for reducing or inactivating contaminant nucleic acids.

US Patent:

20190021633, Jan 24, 2019

Filed:

Nov 21, 2017

Appl. No.:

15/819220

Inventors:

Ling Wang - San Jose CA, US
Karolina Cengija - Hillsboro OR, US
Michael R. Rosen - San Jose CA, US
Naghma Anwar - San Jose CA, US
Thao-Vy Nguyen - San Francisco CA, US

International Classification:

A61B 5/08
A61B 5/00

Abstract:

An example apparatus for detecting respiratory rates includes an audio receiver to receive audio including respiratory sounds. The apparatus also includes an adaptive low-pass filter to process the audio using an adaptive bandwidth based on a mean breath rate to generate an envelope. The apparatus further includes a peak detector to detect a plurality of peaks from the envelope. The apparatus includes a respiratory rate calculator to calculate a respiratory rate based on the detected plurality of peaks.

US Patent:

20180237851, Aug 23, 2018

Filed:

Apr 16, 2018

Appl. No.:

15/953822

Inventors:

- Redwood City CA, US
Igor D. Vilfan - East Palo Alto CA, US
Michael Kertesz - Menlo Park CA, US
Timothy A. Blauwkamp - Palo Alto CA, US
Michael Rosen - Palo Alto CA, US
Rene Sit - Sunnyvale CA, US

International Classification:

C12Q 1/6874
C12Q 1/689
C12N 15/10
G06F 19/22

Abstract:

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.

US Patent:

20180078187, Mar 22, 2018

Filed:

Sep 19, 2016

Appl. No.:

15/269812

Inventors:

- Santa Clara CA, US
Indira Negi - San Jose CA, US
Vivek K. Menon - Overland Park KS, US
Michael R. Rosen - Santa Clara CA, US
Donald L. Gross - Hillsboro OR, US
Ling Wang - San Jose CA, US
Shea M. Dillon - Hillsboro OR, US
Stephen C. Fenwick - Ashland OR, US
Tom L. Simmons - Newbury Park CA, US
Robert M. Negron - Santa Clara CA, US

International Classification:

A61B 5/16
A61B 5/00
A61B 5/024
A61B 5/08
A61B 5/0476

Abstract:

Embodiments of the present disclosure provide techniques and configurations for an apparatus for stress event detection. In some embodiments, the apparatus may be a wearable device and may include at least one first sensor disposed on the wearable apparatus to generate a first sensor signal indicative of a brain activity of a user, at least one second sensor disposed on the wearable apparatus to generate a second sensor signal indicative of a heart rate of the user, and at least one third sensor disposed on the wearable apparatus to generate a third sensor signal indicative of a respiration rate of the user. The apparatus may further include a controller coupled with the at least first, second, and third sensors, to detect a stress event for the user, based at least in part on the first, second, and third sensor signals. Other embodiments may be described and/or claimed.

US Patent:

20170275691, Sep 28, 2017

Filed:

Mar 24, 2017

Appl. No.:

15/469474

Inventors:

- Menlo Park CA, US
Igor D. Vilfan - East Palo Alto CA, US
Michael Kertesz - Menlo Park CA, US
Timothy A. Blauwkamp - Palo Alto CA, US
Michael Rosen - Palo Alto CA, US
Rene Sit - Sunnyvale CA, US

International Classification:

C12Q 1/68
G06F 19/22
C12N 15/10

Abstract:

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.